About: Polyoxazoline thermoresponsive micelles as radionuclide delivery systems

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5–10 105 g mL1 with diameter 200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions. Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5–10 105 g mL1 with diameter 200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions. (en)
Title	Polyoxazoline thermoresponsive micelles as radionuclide delivery systems Polyoxazoline thermoresponsive micelles as radionuclide delivery systems (en)
skos:prefLabel	Polyoxazoline thermoresponsive micelles as radionuclide delivery systems Polyoxazoline thermoresponsive micelles as radionuclide delivery systems (en)
skos:notation	RIV/61389013:_____/10:00346570!RIV11-MSM-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0505), P(GA202/09/2078), P(GPP207/10/P054), P(KAN200200651), Z(AV0Z40500505), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Pánek, Jiří Hrubý, Martin Kučka, Jan Macková, Hana Škodová, Michaela Filippov, Sergey
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	279804
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/10:00346570
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	micelles; drug delivery systems; thermoresponsive polymers (en)
http://linked.open.../riv/klicoveSlovo	micelles thermoresponsive polymers drug delivery systems
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6EDF79C1F2C5]
http://linked.open...i/riv/nazevZdroje	Macromolecular Bioscience
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of targeted therapeutic drugs Nanoparticulate and supramolecular systems for targeted drug delivery Polymeric micelles with metal ion – assembled core Bioinspired nanoparticles sensitive to environment stimuli
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Filippov, Sergey Hrubý, Martin Pánek, Jiří Ulbrich, Karel Kučka, Jan Větvička, David Macková, Hana Nováková, Michaela
http://linked.open...ain/vavai/riv/wos	000281387900011
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Microorganisms in Research and Biotechnology
issn	1616-5187
number of pages	9 (xsd:int)

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