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  • We have synthesized and characterized a thermoresponsive micellar radionuclide delivery systems based on ABA triblock copolymers poly[2-methyl-2-oxazoline - block - (2-isopropyl-2-oxazoline - co - 2-butyl-2-oxazoline) - block - 2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions.
  • We have synthesized and characterized a thermoresponsive micellar radionuclide delivery systems based on ABA triblock copolymers poly[2-methyl-2-oxazoline - block - (2-isopropyl-2-oxazoline - co - 2-butyl-2-oxazoline) - block - 2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions. (en)
Title
  • Thermoresponsive micelles for radionuclide delivery
  • Thermoresponsive micelles for radionuclide delivery (en)
skos:prefLabel
  • Thermoresponsive micelles for radionuclide delivery
  • Thermoresponsive micelles for radionuclide delivery (en)
skos:notation
  • RIV/61389013:_____/10:00342223!RIV11-MSM-61389013
http://linked.open...avai/riv/aktivita
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  • P(1M0505), P(GPP207/10/P054), P(KAN200200651), Z(AV0Z40500505)
http://linked.open...vai/riv/dodaniDat
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  • 292790
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  • RIV/61389013:_____/10:00342223
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  • micelles; drug delivery systems; thermoresponsive polymers (en)
http://linked.open.../riv/klicoveSlovo
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  • [365C3EE5032F]
http://linked.open...v/mistoKonaniAkce
  • Egmond aan Zee
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  • Egmond aan Zee
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  • Abstract Book
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  • Filippov, Sergey
  • Hrubý, Martin
  • Pánek, Jiří
  • Ulbrich, Karel
  • Kučka, Jan
  • Macková, Hana
  • Nováková, Michaela
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
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  • University of Twente
https://schema.org/isbn
  • 978-90-365-3007-1
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