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Description
  • Nové amfifilní HPMA kopolymery byly připraveny jakožto polymerní nosiče protinádorových léčiv (např. doxorubicinu). Ve vodném prostředí kopolymery vytvářely nadmolekulární struktury, proto je možné očekávat zvýšenou akumulaci léčiva v pevných nádorech díky EPR efektu (efekt zvýšené propustnosti a zadržování). Navíc byly vazby mezi hydrofilními polymerními řetězci a hydrofobními molekulami biodegradovatelné, aby byl po splnění funkce nosiče léčiv umožněn rozpad nadmolekulárních struktur a posléze odstranění kopolymerů z těla. (cs)
  • Novel amphiphilic HPMA copolymers designed as polymer carriers of anti-cancer drugs (e.g. doxorubicin) were synthesised. The copolymers formed supramolecular structures in aqueous environment and thus increase drug accumulation in solid tumours due to the EPR (enhanced permeability and retention) effect could be expected. In addition, copolymers contained biodegradable linkages between hydrophilic polymer chains and hydrophobic molecules in order to allow disassembling of the supramolecular structure after completing their drug carrier function and renal removal of copolymers from the body.
  • Novel amphiphilic HPMA copolymers designed as polymer carriers of anti-cancer drugs (e.g. doxorubicin) were synthesised. The copolymers formed supramolecular structures in aqueous environment and thus increase drug accumulation in solid tumours due to the EPR (enhanced permeability and retention) effect could be expected. In addition, copolymers contained biodegradable linkages between hydrophilic polymer chains and hydrophobic molecules in order to allow disassembling of the supramolecular structure after completing their drug carrier function and renal removal of copolymers from the body. (en)
Title
  • Biodegradable high-molecular-weith polymer drug carriers based on HPMA copolymers
  • Biodegradable high-molecular-weith polymer drug carriers based on HPMA copolymers (en)
  • Biodegradovatelné vysokomolekulární polymerní nosiče léčiv na bázi HPMA kopolymerů (cs)
skos:prefLabel
  • Biodegradable high-molecular-weith polymer drug carriers based on HPMA copolymers
  • Biodegradable high-molecular-weith polymer drug carriers based on HPMA copolymers (en)
  • Biodegradovatelné vysokomolekulární polymerní nosiče léčiv na bázi HPMA kopolymerů (cs)
skos:notation
  • RIV/61389013:_____/08:00306675!RIV08-AV0-61389013
http://linked.open.../vavai/riv/strany
  • 229;231
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA400500806), Z(AV0Z40500505)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 358020
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/08:00306675
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • HPMA copolymers; polymer drug carrier; micelles (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [9D8826C240C3]
http://linked.open...v/mistoKonaniAkce
  • Noordwijk aan Zee
http://linked.open...i/riv/mistoVydani
  • Noordwijk aan Zee
http://linked.open...i/riv/nazevZdroje
  • Abstract Book - Tenth European Symposium on Controlled Drug Delivery
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Chytil, Petr
  • Etrych, Tomáš
  • Ulbrich, Karel
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • University of Twente
https://schema.org/isbn
  • 978-90-365-2653-1
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