About: Hydrolytically and reductively degradable high-molecular-weight poly(ethylene glycol)s

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Redukčně degradovatelné multiblokové polymery pro dopravu genů a léčiv byly připraveny oxidační polykondenzací poly(ethylenglykol)-cysteinových derivátů obsahujících esterové nebo urethanové vazby. Byly studovány hydrolýza i redukční degradace glutathionem a dithiothreitolem těchto polymerů. Substituce COOH nebo NH2 skupin v polymerech výrazně ovlivnila rychlost jejich hydrolýzy. Povrchová modifikace poly(L-lysin)-DNA complexů těmito polymery vedla ke vzniku redukčně degradovatelných nanočástic. (cs) Reductively degradable multiblock polymers for gene and drug delivery were synthesised by oxidative polycondensation of poly(ethylene glycol)-cysteine derivatives containing ester or urethane bonds. Hydrolysis and reductive degradation of the polymers with glutathione and dithiothreitol were studied. Chemical substitution of the pendant COOH or NH2 groups significantly affected the rate of the polymer degradation. Surface modification of poly(L-lysine)-DNA complexes with the polymers led to the formation of reductively degradable nanoparticles. Reductively degradable multiblock polymers for gene and drug delivery were synthesised by oxidative polycondensation of poly(ethylene glycol)-cysteine derivatives containing ester or urethane bonds. Hydrolysis and reductive degradation of the polymers with glutathione and dithiothreitol were studied. Chemical substitution of the pendant COOH or NH2 groups significantly affected the rate of the polymer degradation. Surface modification of poly(L-lysine)-DNA complexes with the polymers led to the formation of reductively degradable nanoparticles. (en)
Title	Hydrolytically and reductively degradable high-molecular-weight poly(ethylene glycol)s Hydrolyticky a redukčně degradovatelné vysokomolekulární poly(ethylenglykoly) (cs) Hydrolytically and reductively degradable high-molecular-weight poly(ethylene glycol)s (en)
skos:prefLabel	Hydrolytically and reductively degradable high-molecular-weight poly(ethylene glycol)s Hydrolyticky a redukčně degradovatelné vysokomolekulární poly(ethylenglykoly) (cs) Hydrolytically and reductively degradable high-molecular-weight poly(ethylene glycol)s (en)
skos:notation	RIV/61389013:_____/07:00091296!RIV08-AV0-61389013
http://linked.open.../vavai/riv/strany	2642;2653
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0505), P(KAN200200651), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Pechar, Michal Braunová, Alena Laga, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	425126
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/07:00091296
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biodegradable; drug delivery systems; gene delivery vectors; poly(ethylene glycol) (en)
http://linked.open.../riv/klicoveSlovo	gene delivery vectors biodegradable poly(ethylene glycol) drug delivery systems
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6CADA50F8B2B]
http://linked.open...i/riv/nazevZdroje	Macromolecular Chemistry and Physics
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of targeted therapeutic drugs Nanoparticulate and supramolecular systems for targeted drug delivery
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	208
http://linked.open...iv/tvurceVysledku	Laga, Richard Pechar, Michal Ulbrich, Karel Braunová, Alena
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1352
number of pages	12 (xsd:int)

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