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  • The results show that physicochemical modification affects the pharmacokinetics, the tissue distribution and the tumor accumulation of HPMA copolymers. They also show that, even though absolute levels in blood and tumors decrease significantly upon the introduction of chemical groups, the predominant part of the tumor targeting potential of parental HPMA copolymers can be retained effectively. The data confirm the potential of HPMA copolymers as long-circulating and tumor-targeted drug carriers, and they indicate that polymer-based drug delivery systems may prove to be interesting and useful modalities for more effectively treating various forms of advanced malignancy.
  • The results show that physicochemical modification affects the pharmacokinetics, the tissue distribution and the tumor accumulation of HPMA copolymers. They also show that, even though absolute levels in blood and tumors decrease significantly upon the introduction of chemical groups, the predominant part of the tumor targeting potential of parental HPMA copolymers can be retained effectively. The data confirm the potential of HPMA copolymers as long-circulating and tumor-targeted drug carriers, and they indicate that polymer-based drug delivery systems may prove to be interesting and useful modalities for more effectively treating various forms of advanced malignancy. (en)
  • Výsledky ukazují, že fyzikálně chemická modifikace HPMA kopolymerů ovlivňuje jejich pharmakokinetiku, distribuci v orgánech a akumulaci do nádorů. Výsledky též ukazují, že i když se zavedením chemických skupin absolutní hladiny kopolymeru v krvi a nádorech snižují, prevážná část schopnosti kopolymerů HPMA směrovat do nádoru zústává zachována. Data potvrzují možnosti HPMA kopolymerů jako dlouhocirkulujících cíleně směrovaných nosičů léčiv a indikují, že polymerní systémy pro dopravu léčiv mohou být zajímavou a užitečnou variantou pro léčení různých forem pokročilých stadií nádorových onemocnění. (cs)
Title
  • Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers
  • Vliv fyzikálně chemické modifikace kopolymerů HPMA na jejich biodistribuci a akumulaci v nádorech (cs)
  • Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers (en)
skos:prefLabel
  • Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers
  • Vliv fyzikálně chemické modifikace kopolymerů HPMA na jejich biodistribuci a akumulaci v nádorech (cs)
  • Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers (en)
skos:notation
  • RIV/61389013:_____/05:00030289!RIV06-AV0-61389013
http://linked.open.../vavai/riv/strany
  • 103;118
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA204/05/2255), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 519389
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/05:00030289
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • HPMA; EPR; drug delivery (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [2CC67DD3A233]
http://linked.open...i/riv/nazevZdroje
  • Journal of Controlled Release
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 110
http://linked.open...iv/tvurceVysledku
  • Etrych, Tomáš
  • Pechar, Michal
  • Pola, Robert
  • Ulbrich, Karel
  • Šubr, Vladimír
  • Lammers, T.
  • Storm, G.
  • Peschke, P.
  • Huber, P.
  • Kühnlein, R.
  • Kissel, M.
http://linked.open...n/vavai/riv/zamer
issn
  • 0168-3659
number of pages
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