About: Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice     Goto   Sponge   NotDistinct   Permalink

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Description
  • The hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) was used for RNase A or BS-RNase modification to prevent their degradation in bloodstream or fast elimination. Two PHPMA chains (classic and star-like) were synthesized and their conjugates with both enzymes were tested on the CD-1 nude mice bearing various human tumors.
  • The hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) was used for RNase A or BS-RNase modification to prevent their degradation in bloodstream or fast elimination. Two PHPMA chains (classic and star-like) were synthesized and their conjugates with both enzymes were tested on the CD-1 nude mice bearing various human tumors. (en)
  • Hydrofilní poly[N-(2-hydroxypropyl)methakrylamid] byl použit pro modifikaci RNaseA a BS RNase, aby se zabránilo jejich degradaci v krevním řečišti a jejich rychlému vyloučení. Byly syntetizovány dva PHPMA řetězce (klasický a hvězdicovitý) a jejich konjugáty s oběma enzymy byly testovány na CD-1 myších s různými lidskými nádory. (cs)
Title
  • Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice
  • Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice (en)
  • Polymerní konjugáty hovězí pankreatické a seminální ribonukleasy inhibují růst lidských nádorů u athymických myší (cs)
skos:prefLabel
  • Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice
  • Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice (en)
  • Polymerní konjugáty hovězí pankreatické a seminální ribonukleasy inhibují růst lidských nádorů u athymických myší (cs)
skos:notation
  • RIV/61389013:_____/04:00105719!RIV/2005/GA0/A55005/N
http://linked.open.../vavai/riv/strany
  • 83;92
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA523/01/0114), P(GV307/96/K226), P(KSK4055109), Z(AV0Z4050913), Z(MZ00237360001)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 580196
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/04:00105719
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • RNase A;BS-RNase;polymer conjugates (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [C263DB9FFE96]
http://linked.open...i/riv/nazevZdroje
  • Journal of Controlled Release
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 95
http://linked.open...iv/tvurceVysledku
  • Poučková, P.
  • Strohalm, Jiří
  • Ulbrich, Karel
  • Matoušek, Josef
  • Zadinová, M.
  • Plocová, Daniela
  • Souček, J.
  • Hloušková, D.
  • Špunda, M.
  • Olejár, T.
  • Zitko, M.
http://linked.open...n/vavai/riv/zamer
issn
  • 0168-3659
number of pages
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