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Description
  • Antibody-targeted doxorubicin-containing classic and star conjugates as well as non-targeted polymer hydrazone conjugates are able completely cure the EL 4 lymphoma-bearing mice in contrast to the free doxorubicin. We showed that during the treatment with polymer-doxorubicin conjugates the immune system of treated mice is activated and effective long-term anti-tumor immunity is established.
  • Antibody-targeted doxorubicin-containing classic and star conjugates as well as non-targeted polymer hydrazone conjugates are able completely cure the EL 4 lymphoma-bearing mice in contrast to the free doxorubicin. We showed that during the treatment with polymer-doxorubicin conjugates the immune system of treated mice is activated and effective long-term anti-tumor immunity is established. (en)
  • Na rozdíl od volného doxorubicinu jsou klasické a hvězdicovité konjugáty směrované protilátkou jakožto i nesměrované hydrazonové konjugáty, vždy obsahující doxorubicin, schopny zcela vyléčit myši nesoucí EL4 lymfom. Ukázali jsme, že během léčby polymerními konjugáty doxorubicinu je imunitní systém myší aktivován a vzniká dlouhodobá protinádorová imunita. (cs)
Title
  • Polymer drug carriers for site-specific therapy
  • Polymer drug carriers for site-specific therapy (en)
  • Polymerní nosiče léčiv pro cílenou terapii (cs)
skos:prefLabel
  • Polymer drug carriers for site-specific therapy
  • Polymer drug carriers for site-specific therapy (en)
  • Polymerní nosiče léčiv pro cílenou terapii (cs)
skos:notation
  • RIV/61389013:_____/04:00101308!RIV/2005/GA0/A55005/N
http://linked.open.../vavai/riv/strany
  • 95;97
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/02/1425), P(IAA4050201), P(IBS5020101), Z(AV0Z4050913)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 580189
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/04:00101308
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • antibody-targeted doxorubicin;polymer hydrazone conjugates;long-term anti-tumor immunity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [98F76A150083]
http://linked.open...v/mistoKonaniAkce
  • Changchun
http://linked.open...i/riv/mistoVydani
  • Peking
http://linked.open...i/riv/nazevZdroje
  • Preprints
http://linked.open...in/vavai/riv/obor
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Etrych, Tomáš
  • Kovář, Marek
  • Pechar, Michal
  • Ulbrich, Karel
  • Říhová, Blanka
  • Jelínková, Markéta
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • State Key Laboratory of Polymer Physics and Chemistry
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