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Description
  • Směrující oligopeptid odvozený od lamininu byl kovalentně navázán na N-(2-hydroxypropyl, methakrylamidové kopolymery a byl studován jejich spotřeba rakovinnými prostatickými buňkami. Kopolymery byly rovněž konjugovány s dvěma peptidy odvozenými od hormonu uvolňujícího gonadotropin a následně použity k modifikaci adenovirálních vektorů pro transport genů. Byl prozkoumán vliv polymerního pokryvu, jak s, tak bez směrujícího peptidu, na expresi použitých genů. (cs)
  • A laminin derived targeting oligopeptide sequence was covalently linked to N-(2-hydroxypropyl)methacrylamide based copolymers and the uptake of the polymers to prostate cancer cells was studied. Two peptides derived from gonadotropin. releasing hormone were also conjugated to HPMA copolymers and used for modification of adenoviral gene delivery vectors. The influence of the polymer coating with and without the targeting peptide on the expression of reporter genes was investigated.
  • A laminin derived targeting oligopeptide sequence was covalently linked to N-(2-hydroxypropyl)methacrylamide based copolymers and the uptake of the polymers to prostate cancer cells was studied. Two peptides derived from gonadotropin. releasing hormone were also conjugated to HPMA copolymers and used for modification of adenoviral gene delivery vectors. The influence of the polymer coating with and without the targeting peptide on the expression of reporter genes was investigated. (en)
Title
  • Oligopeptides as targeting structures in cancer therapy
  • Oligopeptides as targeting structures in cancer therapy (en)
  • Oligopeptidy jako směrující struktury při léčbě nádorových onemocnění (cs)
skos:prefLabel
  • Oligopeptides as targeting structures in cancer therapy
  • Oligopeptides as targeting structures in cancer therapy (en)
  • Oligopeptidy jako směrující struktury při léčbě nádorových onemocnění (cs)
skos:notation
  • RIV/61389013:_____/04:00101296!RIV/2005/AV0/A55005/N
http://linked.open.../vavai/riv/strany
  • 185;188
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(KSK4055109), Z(AV0Z4050913)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
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  • 577666
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/04:00101296
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • peptides;gene delivery;adenovirus (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [55BE6417D9E3]
http://linked.open...v/mistoKonaniAkce
  • Noordwijk aan Zee
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  • Noordwijk aan Zee
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  • Proceedings
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Etrych, Tomáš
  • Pechar, Michal
  • Ulbrich, Karel
  • Stevenson, M.
  • Seymour, L.
  • Fabra, A.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • University of Twente
https://schema.org/isbn
  • 90-365-2036-3
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