About: Stability of polycation-DNA complexes: comparison of computer model and experimental data

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polycations containing primary and tertiary amino and quaternary ammonium groups formed stable complexes with DNA only in pure water. Increasing concentration of sodium chloride in the saline solution resulted in dissociation, decomposition of the polyplexes and release of incorporated DNA. Stability of the complexes decreased depending on polycation substituent as follows: primary amine > secondary amine > tertiary amine >quaternary ammonium group. Results of computer modeling of the interaction of the oligocations with a model DNA chain were in good agreement with the experimental data. Polycations containing primary and tertiary amino and quaternary ammonium groups formed stable complexes with DNA only in pure water. Increasing concentration of sodium chloride in the saline solution resulted in dissociation, decomposition of the polyplexes and release of incorporated DNA. Stability of the complexes decreased depending on polycation substituent as follows: primary amine > secondary amine > tertiary amine >quaternary ammonium group. Results of computer modeling of the interaction of the oligocations with a model DNA chain were in good agreement with the experimental data. (en) Polykationty obsahující primární a terciární amino a kvarterní amoniové skupiny tvoří stabilní komplexy s DNA pouze v čisté vodě. S rostoucí koncentrací chloridu sodného docházelo k disociaci polyplexů a uvolnění DNA. Stabilita komplexů klesala v pořadí primární > sekundární > terciární > kvarterní amoniová skupina. Výsledky počítačového modelování interakcí oligokationtu s modelem řetězce DNA byly v dobrém souhlasu s experimentálními daty. (cs)
Title	Stability of polycation-DNA complexes: comparison of computer model and experimental data Stability of polycation-DNA complexes: comparison of computer model and experimental data (en) Stabilita komplexů polykationt-DNA: porovnání počítačového modelu a experimentálních dat (cs)
skos:prefLabel	Stability of polycation-DNA complexes: comparison of computer model and experimental data Stability of polycation-DNA complexes: comparison of computer model and experimental data (en) Stabilita komplexů polykationt-DNA: porovnání počítačového modelu a experimentálních dat (cs)
skos:notation	RIV/61389013:_____/04:00101286!RIV/2005/AV0/A55005/N
http://linked.open.../vavai/riv/strany	3;6
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KSK4055109), Z(AV0Z4050913)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Dybal, Jiří Ulbrich, Karel Reschel, Tomáš Huml, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	587703
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/04:00101286
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polycation-DNA complexes;gene delivery;quantum mechanical calculations (en)
http://linked.open.../riv/klicoveSlovo	polycation-DNA complexes gene delivery quantum mechanical calculations
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B82FBAAB526B]
http://linked.open...i/riv/nazevZdroje	Materials Structure
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Physics, chemistry and informatics for biological, ecological and medicinal applications
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Dybal, Jiří Ulbrich, Karel Kabeláč, Martin Huml, Karel Reschel, Tomáš
http://linked.open...n/vavai/riv/zamer	Cílená syntéza a studium chemických, fyzikálně-chemických a fyzikálních vlastností makromolekulárních a nadmolekulárních látek a soustav pro vyspělé technologie
issn	1211-5894
number of pages	4 (xsd:int)

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