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rdf:type
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Description
| - A set of four water-soluble (3-methoxypropyl)stannanes of general formula (CH3OCH2CH2CH2)(x)SnCl4-x, where x = 4 (1), x = 3 (2), x = 2 (3), and x = 1 (4), was prepared. For 3 and 4, which were isolated in the crystalline state, it was shown by X-ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometries, respectively (i.e., the oxygen atoms of the 3-methoxypropyl groups were coordinated to the central tin atom in both cases, forming chelates). For all compounds, structures in CDCl3 and [D-6]DMSO solutions were proposed on the basis of their C-13 and Sn-119 NMR spectra. In CDCl3 solution, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of the 3-methoxypropyl substituent was evaluated on the basis of O-17 NMR chemical shifts and 3,6J(H-1,Sn-119) long-range coupling constants. Compounds 2 and 3 exhibited promising antitumour and trypanocidal activities in vitro.
- A set of four water-soluble (3-methoxypropyl)stannanes of general formula (CH3OCH2CH2CH2)(x)SnCl4-x, where x = 4 (1), x = 3 (2), x = 2 (3), and x = 1 (4), was prepared. For 3 and 4, which were isolated in the crystalline state, it was shown by X-ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometries, respectively (i.e., the oxygen atoms of the 3-methoxypropyl groups were coordinated to the central tin atom in both cases, forming chelates). For all compounds, structures in CDCl3 and [D-6]DMSO solutions were proposed on the basis of their C-13 and Sn-119 NMR spectra. In CDCl3 solution, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of the 3-methoxypropyl substituent was evaluated on the basis of O-17 NMR chemical shifts and 3,6J(H-1,Sn-119) long-range coupling constants. Compounds 2 and 3 exhibited promising antitumour and trypanocidal activities in vitro. (en)
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Title
| - Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides.
- Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. (en)
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skos:prefLabel
| - Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides.
- Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. (en)
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skos:notation
| - RIV/61389013:_____/03:55033007!RIV/2004/AV0/A55004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LN00A028), Z(AV0Z4050913)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61389013:_____/03:55033007
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tin; chelates; O ligands (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - European Journal of Inorganic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brus, Jiří
- Bruhn, C.
- Lébl, T.
- Smička, A.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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