About: Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

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About: Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We synthesized novel bioconjugates of cathepsin K inhibitor, 1-(N-benzyl-oxy-carbonylleucyl)-5-(phenylalanylleucyl)-carbo-hydrazide with a-methoxy poly(ethylene glycol), semitelechelic poly[N-(2-hydroxypropyl)-methacrylamide] and HPMA copolymers containing reactive side-chans. The inhibitory activity of macromolecular inhibitors for cysteine proteinases as well as their ability to inhibit cathepsin K activity in synovial fibroblasts were evaluated. We synthesized novel bioconjugates of cathepsin K inhibitor, 1-(N-benzyl-oxy-carbonylleucyl)-5-(phenylalanylleucyl)-carbo-hydrazide with a-methoxy poly(ethylene glycol), semitelechelic poly[N-(2-hydroxypropyl)-methacrylamide] and HPMA copolymers containing reactive side-chans. The inhibitory activity of macromolecular inhibitors for cysteine proteinases as well as their ability to inhibit cathepsin K activity in synovial fibroblasts were evaluated. (en)
Title	Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. (en)
skos:prefLabel	Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. (en)
skos:notation	RIV/61389013:_____/02:55023337!RIV/2003/AV0/A55003/N
http://linked.open.../vavai/riv/strany	12;13
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KSK4055109), Z(AV0Z4050913)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Pechar, Michal
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	639607
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/02:55023337
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cathepsin K (en)
http://linked.open.../riv/klicoveSlovo	Cathepsin K
http://linked.open...ontrolniKodProRIV	[6A2561C14804]
http://linked.open...v/mistoKonaniAkce	Istanbul [TR]
http://linked.open...i/riv/mistoVydani	Istanbul
http://linked.open...i/riv/nazevZdroje	Intelligent Drug Delivery Systems Better and Safer Therapy.
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Physics, chemistry and informatics for biological, ecological and medicinal applications
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Kopeček, J. Pechar, Michal Wang, D. Kopečková, P. Brömme, D.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2002-09-09 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Cílená syntéza a studium chemických, fyzikálně-chemických a fyzikálních vlastností makromolekulárních a nadmolekulárních látek a soustav pro vyspělé technologie
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Hacettepe University Pharmacy Faculty
https://schema.org/isbn	975-491-126-6

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