Attributes | Values |
---|
rdf:type
| |
Description
| - We have designed, synthesized, and evaluated new lysosomotropic (water-soluble) polymer-cathepsin K inhibitor conjugates. A potent selective cathepsin K inhibitor, 1,5-bis(N-benzyloxycarbonylleucyl)carbohydrazide, was modified to 1-(N-benzyloxycarbonylleucyl)-5-(phenylalanylleucyl)carbohydrazide to facilitate polymer conjugation. It was conjugated to the polymer chain termini of two watersoluble polymers alpha-methoxy poly(ethylene glycol) and semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].
- We have designed, synthesized, and evaluated new lysosomotropic (water-soluble) polymer-cathepsin K inhibitor conjugates. A potent selective cathepsin K inhibitor, 1,5-bis(N-benzyloxycarbonylleucyl)carbohydrazide, was modified to 1-(N-benzyloxycarbonylleucyl)-5-(phenylalanylleucyl)carbohydrazide to facilitate polymer conjugation. It was conjugated to the polymer chain termini of two watersoluble polymers alpha-methoxy poly(ethylene glycol) and semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]. (en)
|
Title
| - Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.
- Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors. (en)
|
skos:prefLabel
| - Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.
- Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors. (en)
|
skos:notation
| - RIV/61389013:_____/02:55023136!RIV/2003/AV0/A55003/N
|
http://linked.open.../vavai/riv/strany
| |
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - P(KSK4055109), Z(AV0Z4050913)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/61389013:_____/02:55023136
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - cathepsin K; enzymes (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| |
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...ocetUcastnikuAkce
| |
http://linked.open...nichUcastnikuAkce
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Kopeček, J.
- Pechar, Michal
- Wang, D.
- Kopečková, P.
- Brömme, D.
- Weijie, L.
|
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |