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  • In this chapter, a more detailed influences of various biochemical factors will be added into the bone remodelling model through the RANKL-RANK-OPG chain mediating the effects of majority of acting hormones, growth factors, and cytokines. Physical activity (dynamic loading) is very essential in bone adaptation process. The addition of control factors will enable to predict concrete effects of changes of serum levels of these control factors of bone remodelling such as PTH, NO. The possibility of including vitamin D and TGF-beta into the model is also being discussed. Several diseases and their possible treatment is simulated, e.g. influence of menopause, hyperparathyroidism, and disuse.
  • In this chapter, a more detailed influences of various biochemical factors will be added into the bone remodelling model through the RANKL-RANK-OPG chain mediating the effects of majority of acting hormones, growth factors, and cytokines. Physical activity (dynamic loading) is very essential in bone adaptation process. The addition of control factors will enable to predict concrete effects of changes of serum levels of these control factors of bone remodelling such as PTH, NO. The possibility of including vitamin D and TGF-beta into the model is also being discussed. Several diseases and their possible treatment is simulated, e.g. influence of menopause, hyperparathyroidism, and disuse. (en)
Title
  • Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment
  • Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment (en)
skos:prefLabel
  • Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment
  • Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment (en)
skos:notation
  • RIV/61388998:_____/11:00370475!RIV12-AV0-61388998
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA106/08/0557), Z(AV0Z20760514), Z(MSM6840770010)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 199461
http://linked.open...ai/riv/idVysledku
  • RIV/61388998:_____/11:00370475
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • bone remodelling; biomechanics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [5D1DFA049764]
http://linked.open...i/riv/mistoVydani
  • Rijeka
http://linked.open...i/riv/nazevZdroje
  • Theoretical Biomechanics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Maršík, František
  • Klika, Václav
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • InTech
https://schema.org/isbn
  • 978-953-307-851-9
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