About: The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches

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About: The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions.While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation–contraction coupling. The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions.While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation–contraction coupling. (en)
Title	The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches (en)
skos:prefLabel	The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches (en)
skos:notation	RIV/61388998:_____/09:00324371!RIV10-AV0-61388998
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z20760514)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pásek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav termomechaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	339734
http://linked.open...ai/riv/idVysledku	RIV/61388998:_____/09:00324371
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cardiac cell; t-tubules; excitation-contraction coupling; mathematical modelling (en)
http://linked.open.../riv/klicoveSlovo	cardiac cell mathematical modelling t-tubules excitation-contraction coupling
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B3B8110D11FA]
http://linked.open...i/riv/nazevZdroje	Experimental Physiology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	94
http://linked.open...iv/tvurceVysledku	Pásek, Michal Orchard, C. Brette, F.
http://linked.open...ain/vavai/riv/wos	000265186600005
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics
issn	0958-0670
number of pages	11 (xsd:int)

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