About: Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Práce prezentuje výsledky experimentálních měření účinků psychofarmaka perfenazinu na rychlý sodíkový proud (INa) a přechodný draslíkový proud (Ito) u komorových buněk potkana. Mechanizmus blokády obou proudů je vyšetřován prostřednictvím matematických modelů. (cs) The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24 +/- 0.10 μmol/l, nH =0.99 +/- 0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 +/- 3.5 μmol/l, nH = 0.75 +/- 0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 μmol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states. The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24 +/- 0.10 μmol/l, nH =0.99 +/- 0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 +/- 3.5 μmol/l, nH = 0.75 +/- 0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 μmol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states. (en)
Title	Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study (en) Blokáda sodíkového a přechodného draslíkového proudu perfenazinem: experimentální a simulační studie (cs)
skos:prefLabel	Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study (en) Blokáda sodíkového a přechodného draslíkového proudu perfenazinem: experimentální a simulační studie (cs)
skos:notation	RIV/61388998:_____/08:00314950!RIV09-AV0-61388998
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z20760514)
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pásek, Michal
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav termomechaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	386308
http://linked.open...ai/riv/idVysledku	RIV/61388998:_____/08:00314950
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sodium current; potassium outward current; simulation (en)
http://linked.open.../riv/klicoveSlovo	sodium current simulation potassium outward current
http://linked.open...ontrolniKodProRIV	[4AA487A9EAF2]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Analysis of Biomedical Signals and Images
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Pásek, Michal Šimurda, J. Matejovič, P. Nováková, M. Bébarová, M. Jansová, D. Šimurdová, M.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2008-06-29 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Vysoké učení technické v Brně. Nakladatelství VUTIUM
https://schema.org/isbn	978-80-214-3612-1

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