Attributes | Values |
---|
rdf:type
| |
Description
| - Práce prezentuje výsledky experimentálních měření účinků psychofarmaka perfenazinu na rychlý sodíkový proud (INa) a přechodný draslíkový proud (Ito) u komorových buněk potkana. Mechanizmus blokády obou proudů je vyšetřován prostřednictvím matematických modelů. (cs)
- The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24 +/- 0.10 μmol/l, nH =0.99 +/- 0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 +/- 3.5 μmol/l, nH = 0.75 +/- 0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 μmol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states.
- The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24 +/- 0.10 μmol/l, nH =0.99 +/- 0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 +/- 3.5 μmol/l, nH = 0.75 +/- 0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 μmol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states. (en)
|
Title
| - Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study
- Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study (en)
- Blokáda sodíkového a přechodného draslíkového proudu perfenazinem: experimentální a simulační studie (cs)
|
skos:prefLabel
| - Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study
- Perphenazine-induced block of sodium and transient outward potassium current: experimental and simulation study (en)
- Blokáda sodíkového a přechodného draslíkového proudu perfenazinem: experimentální a simulační studie (cs)
|
skos:notation
| - RIV/61388998:_____/08:00314950!RIV09-AV0-61388998
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/61388998:_____/08:00314950
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - sodium current; potassium outward current; simulation (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...v/mistoKonaniAkce
| |
http://linked.open...i/riv/mistoVydani
| |
http://linked.open...i/riv/nazevZdroje
| - Analysis of Biomedical Signals and Images
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...iv/tvurceVysledku
| - Pásek, Michal
- Šimurda, J.
- Matejovič, P.
- Nováková, M.
- Bébarová, M.
- Jansová, D.
- Šimurdová, M.
|
http://linked.open...vavai/riv/typAkce
| |
http://linked.open.../riv/zahajeniAkce
| |
http://linked.open...n/vavai/riv/zamer
| |
number of pages
| |
http://purl.org/ne...btex#hasPublisher
| - Vysoké učení technické v Brně. Nakladatelství VUTIUM
|
https://schema.org/isbn
| |