About: Computer Modelling in Cardiac Cell Electrophysiology     Goto   Sponge   NotDistinct   Permalink

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Description
  • Práce popisuje dlouhou historii vývoje matematických modelů srdečních buněk a zároveň vystihuje jejich neocenitelnou roli v postupném objasňování složitých elektrofyziologických dějů, které na buněčné úrovni srdečního svalu probíhají. (cs)
  • Experimentally based models of cardiac cells have been developed since 1960. The early models were based on extension of the Hodgkin-Huxley nerve impulse equations. Including only a few membrane currents they were able to successfully reconstruct the depolarization and repolarization of cellular membrane. Since that time, the models have underwent extensive modifications and reached a high degree of physiological detail. This short review is aimed to outline the history of their development and show the importance of computer modelling for the research in cardiac cell electrophysiology.
  • Experimentally based models of cardiac cells have been developed since 1960. The early models were based on extension of the Hodgkin-Huxley nerve impulse equations. Including only a few membrane currents they were able to successfully reconstruct the depolarization and repolarization of cellular membrane. Since that time, the models have underwent extensive modifications and reached a high degree of physiological detail. This short review is aimed to outline the history of their development and show the importance of computer modelling for the research in cardiac cell electrophysiology. (en)
Title
  • Computer Modelling in Cardiac Cell Electrophysiology
  • Computer Modelling in Cardiac Cell Electrophysiology (en)
  • Výpočtové modelování v srdeční celulární elektrofyziologii (cs)
skos:prefLabel
  • Computer Modelling in Cardiac Cell Electrophysiology
  • Computer Modelling in Cardiac Cell Electrophysiology (en)
  • Výpočtové modelování v srdeční celulární elektrofyziologii (cs)
skos:notation
  • RIV/61388998:_____/08:00314930!RIV09-AV0-61388998
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z20760514)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 360896
http://linked.open...ai/riv/idVysledku
  • RIV/61388998:_____/08:00314930
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • electrophysiology; cardiac cell; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [3DB66A1C07EA]
http://linked.open...i/riv/nazevZdroje
  • Engineering Mechanics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 15
http://linked.open...iv/tvurceVysledku
  • Pásek, Michal
http://linked.open...n/vavai/riv/zamer
issn
  • 1802-1484
number of pages
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