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rdf:type
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Description
| - The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.
- The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range. (en)
- Příspěvek popisuje využití matematického modelu pro odhad frakční plochy tubulární membrány u komorových buněk laboratorního potkana a pro analýzu faktorů podílejících se na rozporu experimentálních dat určujících tento parametr. (cs)
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Title
| - Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.
- Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte. (en)
- Využití matematického modelu pro odhad frakční plochy tubulární membrány u srdečních komorových buněk. (cs)
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skos:prefLabel
| - Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.
- Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte. (en)
- Využití matematického modelu pro odhad frakční plochy tubulární membrány u srdečních komorových buněk. (cs)
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skos:notation
| - RIV/61388998:_____/07:00087168!RIV08-AV0-61388998
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388998:_____/07:00087168
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cardiac cell; transverse-axial tubular system; tubular membrane area; quantitative modelling (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Engineering Mechanics 2007 : national conference with international participation : book of extended abstracts
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Pásek, Michal
- Šimurda, J.
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - Ústav termomechaniky AV ČR
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https://schema.org/isbn
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