About: Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.     Goto   Sponge   NotDistinct   Permalink

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Description
  • The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.
  • The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range. (en)
  • Příspěvek popisuje využití matematického modelu pro odhad frakční plochy tubulární membrány u komorových buněk laboratorního potkana a pro analýzu faktorů podílejících se na rozporu experimentálních dat určujících tento parametr. (cs)
Title
  • Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.
  • Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte. (en)
  • Využití matematického modelu pro odhad frakční plochy tubulární membrány u srdečních komorových buněk. (cs)
skos:prefLabel
  • Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.
  • Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte. (en)
  • Využití matematického modelu pro odhad frakční plochy tubulární membrány u srdečních komorových buněk. (cs)
skos:notation
  • RIV/61388998:_____/07:00087168!RIV08-AV0-61388998
http://linked.open.../vavai/riv/strany
  • 213;214
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z20760514)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 456961
http://linked.open...ai/riv/idVysledku
  • RIV/61388998:_____/07:00087168
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cardiac cell; transverse-axial tubular system; tubular membrane area; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [E552D88B2298]
http://linked.open...v/mistoKonaniAkce
  • Svratka
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Engineering Mechanics 2007 : national conference with international participation : book of extended abstracts
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Pásek, Michal
  • Šimurda, J.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Ústav termomechaniky AV ČR
https://schema.org/isbn
  • 978-80-87012-06-2
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