About: Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs.     Goto   Sponge   NotDistinct   Permalink

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  • Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed.
  • Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed. (en)
Title
  • Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs.
  • Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs. (en)
skos:prefLabel
  • Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs.
  • Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs. (en)
skos:notation
  • RIV/61388998:_____/02:51020140!RIV/2003/AV0/A51003/N
http://linked.open.../vavai/riv/strany
  • 214;216
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z2076919)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 669371
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  • RIV/61388998:_____/02:51020140
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  • cardiac cell; sodium current; antiarrhythmic drugs (en)
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http://linked.open...ontrolniKodProRIV
  • [2D54790CA923]
http://linked.open...v/mistoKonaniAkce
  • Brno [CZ]
http://linked.open...i/riv/mistoVydani
  • Brno
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  • Analysis of Biomedical Signals and Images.
http://linked.open...in/vavai/riv/obor
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  • Pásek, Michal
  • Šimurda, J.
  • Šimurdová, M.
  • Bahníková, M.
  • Matějovič, P.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Vysoké učení technické v Brně
https://schema.org/isbn
  • 80-214-2120-7
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