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| Description
| - A synthesis of the first double-decker sandwich ion [(1,2-C 2B 9H 11)-3,3-Co-(1,2-C 2B 8H 10)-6,3“-Co-(1“,2“-C 2B 9H 11)] 2- (DD 2-) derivatives is described, having been developed in connection with our search for biologically active substances. A series of B-substituted hydroxyl derivatives was prepared by direct hydroxylation of the ion using aqueous sulfuric acid. Two isomers of monohydroxy derivatives were isolated. The main product was substituted at the central 'canastide' ion fragment, whereas the substitution site for the minor isomer corresponded to a B(8) atom of one of the terminal 11-vertex dicarbollide parts. Similarly, the disubstitution occurred slightly more preferentially on the canastide fragment providing the main isomeric derivative with a symmetric structure. The cesium salt of this ion was characterized by X-ray diffraction. Two other isomeric species have one substituent sitting on the canastide ion and the second present on the dicarbollide ligand in apart or syn-geometric arrangement. A new zwitterion anion [(1,2-C 2B 9H 11)-3,3-Co-(8-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)-] 1- was prepared by the reaction of the parent ion with tetrahydrofuran (THF), activated by BF 3OEt 2. This new compound serves as a versatile building block for constructing organic derivatives, as exemplified by the ring cleavage by various amines or phenolate ions and the synthesis of a basic series of compounds of general formulation [(1,2-C 2B 9H 11)-3,3-Co-(8-X-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)] n- where the organic end-groups X adjacent to the canastide moiety via a B-oxatetramethylene spacer corresponds to C 4H 9NH 2, NC 5H 2, N(C 2H 5) 3, (C 6H 5) 3P (n = 1), or (4-t-Bu-C 6H 4-1-O)- and (2-CH 3O-C 6H 4O) - (n = 2). . All compounds were characterized by high-resolution NMR ( 1H, 13C, and 11B) and mass spectrometry.
- A synthesis of the first double-decker sandwich ion [(1,2-C 2B 9H 11)-3,3-Co-(1,2-C 2B 8H 10)-6,3“-Co-(1“,2“-C 2B 9H 11)] 2- (DD 2-) derivatives is described, having been developed in connection with our search for biologically active substances. A series of B-substituted hydroxyl derivatives was prepared by direct hydroxylation of the ion using aqueous sulfuric acid. Two isomers of monohydroxy derivatives were isolated. The main product was substituted at the central 'canastide' ion fragment, whereas the substitution site for the minor isomer corresponded to a B(8) atom of one of the terminal 11-vertex dicarbollide parts. Similarly, the disubstitution occurred slightly more preferentially on the canastide fragment providing the main isomeric derivative with a symmetric structure. The cesium salt of this ion was characterized by X-ray diffraction. Two other isomeric species have one substituent sitting on the canastide ion and the second present on the dicarbollide ligand in apart or syn-geometric arrangement. A new zwitterion anion [(1,2-C 2B 9H 11)-3,3-Co-(8-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)-] 1- was prepared by the reaction of the parent ion with tetrahydrofuran (THF), activated by BF 3OEt 2. This new compound serves as a versatile building block for constructing organic derivatives, as exemplified by the ring cleavage by various amines or phenolate ions and the synthesis of a basic series of compounds of general formulation [(1,2-C 2B 9H 11)-3,3-Co-(8-X-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)] n- where the organic end-groups X adjacent to the canastide moiety via a B-oxatetramethylene spacer corresponds to C 4H 9NH 2, NC 5H 2, N(C 2H 5) 3, (C 6H 5) 3P (n = 1), or (4-t-Bu-C 6H 4-1-O)- and (2-CH 3O-C 6H 4O) - (n = 2). . All compounds were characterized by high-resolution NMR ( 1H, 13C, and 11B) and mass spectrometry. (en)
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| Title
| - Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances
- Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances (en)
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| skos:prefLabel
| - Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances
- Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances (en)
|
| skos:notation
| - RIV/61388980:_____/12:00383643!RIV13-AV0-61388980
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61388980:_____/12:00383643
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - AIDS treatment; boranes; canastide ion; carboranes; dicarbollides; HIV-protease (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Pure and Applied Chemistry
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Císařová, I.
- Grüner, Bohumír
- Hájková, Zuzana
- Konvalinka, Jan
- Pokorná, Jana
- Švec, Petr
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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