About: Chemical composition with borane clusters for use as an HIV protease inhibitor

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8013190.PN.&OS=PN/8013190&RS=PN/8013190
Description	The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, -1 or -2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability. The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, -1 or -2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability. (en)
Title	Chemical composition with borane clusters for use as an HIV protease inhibitor Chemical composition with borane clusters for use as an HIV protease inhibitor (en)
skos:prefLabel	Chemical composition with borane clusters for use as an HIV protease inhibitor Chemical composition with borane clusters for use as an HIV protease inhibitor (en)
skos:notation	RIV/61388980:_____/11:00371074!RIV12-AV0-61388980
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z40320502), Z(AV0Z40550506)
http://linked.open...cisloPatentuVzoru	US8013190
http://linked.open...eleniPatentuVzoru	2011-09-06 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Grüner, Bohumír Plešek, Jaromír
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav anorganické chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	190118
http://linked.open...ai/riv/idVysledku	RIV/61388980:_____/11:00371074
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV protease inhibitor (en)
http://linked.open.../riv/klicoveSlovo	HIV protease inhibitor
http://linked.open...ontrolniKodProRIV	[A3E32A507B2A]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	Alexandria
http://linked.open...atelePatentuVzoru	United States Patent and Trademark Office (USPTO)
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...ydaniPatentuVzoru	US - Spojené státy americké
http://linked.open...iv/tvurceVysledku	Bodem, J. Cígler, Petr Grüner, Bohumír Král, V. Konvalinka, Jan Kožíšek, Milan Kräusslich, H. G. Lepšík, Martin Plešek, Jaromír Pokorná, Jana Prejdová, Jana
http://linked.open...mniOchranaPatentu	B - USTPO (Úřad pro patenty a ochranné známky USA)
http://linked.open...avai/riv/vlastnik	Ústav organické chemie a biochemie AV ČR, v. v. i. - Vysoká škola chemicko-technologická v Praze - Ústav anorganické chemie AV ČR, v. v. i. - Department of Virology, University of Heidelberg, Heidelberg, DE
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	A - Pouze udělený nebo využívaný pouze vlastníkem
http://linked.open...n/vavai/riv/zamer	Design, syntéza a charakterizace klastrů, kompozitů, komplexů a dalších sloučenin na bázi anorganických látek; mechanismy a kinetika jejich interakcí Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
http://linked.open...stnikPatentuVzoru	Ústav organické chemie a biochemie AV ČR, v. v. i. - Vysoká škola chemicko-technologická v Praze - Ústav anorganické chemie AV ČR, v. v. i. - Department of Virology, University of Heidelberg, Heidelberg, DE

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