About: Stroma as an Active Player in the Development of the Tumor Microenvironment

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The stroma is a considerable part of the tumor microenvironment. Because of its complexity, it can influence both cancer and immune cells in their behavior and cross-talk. Aside from soluble products released by non-cancer and cancer cells, extracellular matrix components have been increasingly recognized as more thanjust minor players in the constitution, development and regulation of the tumor microenvironment. The variations in the connective scaffold architecture, inducedby transforming growth factor beta, lysyl oxidase and metalloproteinase activity,create different conditions of ECM density and stiffness. They exert broad effects on immune cells (e.g. physical barriers, modulation by release of stored TGF-β1), mesenchymal cells (transition to myofibroblasts), epithelial cells (epithelial-to-mesenchymal transition), cancer cells (progression to metastatic phenotype) and stem cells (activation of differentiation addressed by the microenvironment characteristics). Physiological mechanisms of the wound healing process, as well as mechanisms of fibrosis in some chronic pathologies, closelyrecall aspects of cancer deregulated biology. The stroma is a considerable part of the tumor microenvironment. Because of its complexity, it can influence both cancer and immune cells in their behavior and cross-talk. Aside from soluble products released by non-cancer and cancer cells, extracellular matrix components have been increasingly recognized as more thanjust minor players in the constitution, development and regulation of the tumor microenvironment. The variations in the connective scaffold architecture, inducedby transforming growth factor beta, lysyl oxidase and metalloproteinase activity,create different conditions of ECM density and stiffness. They exert broad effects on immune cells (e.g. physical barriers, modulation by release of stored TGF-β1), mesenchymal cells (transition to myofibroblasts), epithelial cells (epithelial-to-mesenchymal transition), cancer cells (progression to metastatic phenotype) and stem cells (activation of differentiation addressed by the microenvironment characteristics). Physiological mechanisms of the wound healing process, as well as mechanisms of fibrosis in some chronic pathologies, closelyrecall aspects of cancer deregulated biology. (en)
Title	Stroma as an Active Player in the Development of the Tumor Microenvironment Stroma as an Active Player in the Development of the Tumor Microenvironment (en)
skos:prefLabel	Stroma as an Active Player in the Development of the Tumor Microenvironment Stroma as an Active Player in the Development of the Tumor Microenvironment (en)
skos:notation	RIV/61388971:_____/14:00436418!RIV15-AV0-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(IAA500200917)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vannucci, Luca
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	47780
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/14:00436418
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor stroma; tumor microenvironment; fibrosis (en)
http://linked.open.../riv/klicoveSlovo	tumor stroma tumor microenvironment fibrosis
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[40BDEE9CE645]
http://linked.open...i/riv/nazevZdroje	Cancer Microenvironment
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetics and immunity in early stages of colorectal adenocarcinoma: inflammatory environment inconventional vs germ-free animal models, and in human samples
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Vannucci, Luca
issn	1875-2292
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s12307-014-0150-x

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