About: Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Silymarin, a crude extract of the seeds of Silybum marianum L. Gaertn., is widely used as an ingredient of nutraceuticals and functional food and also as therapeutics against mild liver afflictions. Most of the beneficial effects of silymarin have traditionally been ascribed to its major component - silybin. The influence of several minor constituents of the crude extract was often neglected, mostly due to their difficult isolation. In this work, we report on the development of a novel separation method using Sephadex LH-20 chromatography employing methanol as a mobile phase. Using this procedure, we were even able to separate polyphenols of identical molecular weight (isobaric), yielding ca 200 to 500 mg of the particular rare flavonolignans such as silydianin and silychristin out of a 4 g silymarin mixture within one day. Silymarin, a crude extract of the seeds of Silybum marianum L. Gaertn., is widely used as an ingredient of nutraceuticals and functional food and also as therapeutics against mild liver afflictions. Most of the beneficial effects of silymarin have traditionally been ascribed to its major component - silybin. The influence of several minor constituents of the crude extract was often neglected, mostly due to their difficult isolation. In this work, we report on the development of a novel separation method using Sephadex LH-20 chromatography employing methanol as a mobile phase. Using this procedure, we were even able to separate polyphenols of identical molecular weight (isobaric), yielding ca 200 to 500 mg of the particular rare flavonolignans such as silydianin and silychristin out of a 4 g silymarin mixture within one day. (en)
Title	Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel (en)
skos:prefLabel	Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel (en)
skos:notation	RIV/61388971:_____/14:00435528!RIV15-GA0-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP301/11/0662), P(LD13041), P(LH13097)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Biedermann, David Křen, Vladimír Křenek, Karel Marhol, Petr Peikerová, Žaneta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	39062
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/14:00435528
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	silymarin; silybin; nutraceutical (en)
http://linked.open.../riv/klicoveSlovo	nutraceutical silybin silymarin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A931B99B422C]
http://linked.open...i/riv/nazevZdroje	Food Research International
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Supramolecular antioxidants protecting proteins against oxidative damage Elucidation of the mechanism of flavonoid-dependent cardioprotection and changes in the bioenergetic status of the cell Silybin and its new congeners - possibilities in the adjuvant cancer treatment
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Křenek, Karel Marhol, Petr Biedermann, David Peikerová, Žaneta
http://linked.open...ain/vavai/riv/wos	000347756000016
issn	0963-9969
number of pages	6 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software