About: Chemistry of silybin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared (en)
Title	Chemistry of silybin Chemistry of silybin (en)
skos:prefLabel	Chemistry of silybin Chemistry of silybin (en)
skos:notation	RIV/61388971:_____/14:00433202!RIV15-GA0-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP301/11/0662), P(LD13042), P(LD14096), P(LH13097)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Biedermann, David Vavříková, Eva Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	7111
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/14:00433202
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	silybin; Silybum marianum; separation (en)
http://linked.open.../riv/klicoveSlovo	separation silybin Silybum marianum
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EE05F0D86408]
http://linked.open...i/riv/nazevZdroje	Natural Product Reports
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Enzymatic synthesis of multivalent glycoconjugates of natural and biologically active compounds. Elucidation of the mechanism of flavonoid-dependent cardioprotection and changes in the bioenergetic status of the cell Chemoprotektivní a biologické aktivity nových dehydro-derivátů flavonolignanů silymarinu. Silybin and its new congeners - possibilities in the adjuvant cancer treatment
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Vavříková, Eva Biedermann, David Cvak, L.
http://linked.open...ain/vavai/riv/wos	000341065600003
issn	0265-0568
number of pages	20 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c3np70122k

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