About: The invertebrate immune system as a model for investigating the environmental impact of nanoparticles

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory effects of nanoparticles and may provide a basis for designing environmentally safer nanomaterials. Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory effects of nanoparticles and may provide a basis for designing environmentally safer nanomaterials. (en)
Title	The invertebrate immune system as a model for investigating the environmental impact of nanoparticles The invertebrate immune system as a model for investigating the environmental impact of nanoparticles (en)
skos:prefLabel	The invertebrate immune system as a model for investigating the environmental impact of nanoparticles The invertebrate immune system as a model for investigating the environmental impact of nanoparticles (en)
skos:notation	RIV/61388971:_____/13:00425739!RIV15-AV0-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0055)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Procházková, Petra
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	81059
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/13:00425739
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Invertebrate; innate immunity; hemocyte (en)
http://linked.open.../riv/klicoveSlovo	innate immunity Invertebrate hemocyte
http://linked.open...ontrolniKodProRIV	[03FA6BED23E9]
http://linked.open...i/riv/mistoVydani	Oxford
http://linked.open...i/riv/nazevZdroje	Nanoparticles and the Immune System
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	138 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Establishment of teams for The center of microbiology and immunology
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Procházková, Petra Canesi, L.
number of pages	22 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Academic Press, Elsevier Inc
https://schema.org/isbn	978-0-12-408085-0

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