About: Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ     Goto   Sponge   NotDistinct   Permalink

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  • Two putative methyltrasferases LmbJ and CcbJ from the biosynthesis of lincosamide antibiotics lincomycin and celesticetin respectively, were characterized biochemicalla and confirmed do possess a homooligomeric, probably hexameric quaternary structure. LmbJ was confirmed to convert N-demethyl lincomycin. CcbJ is able to catalyze the same reaction with comparable efficiency, indicating tha its substrate specificity is somewhat relaxed.
  • Two putative methyltrasferases LmbJ and CcbJ from the biosynthesis of lincosamide antibiotics lincomycin and celesticetin respectively, were characterized biochemicalla and confirmed do possess a homooligomeric, probably hexameric quaternary structure. LmbJ was confirmed to convert N-demethyl lincomycin. CcbJ is able to catalyze the same reaction with comparable efficiency, indicating tha its substrate specificity is somewhat relaxed. (en)
Title
  • Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ
  • Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ (en)
skos:prefLabel
  • Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ
  • Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ (en)
skos:notation
  • RIV/61388971:_____/13:00425635!RIV14-MSM-61388971
http://linked.open...avai/riv/aktivita
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  • I, P(EE2.3.20.0055), P(EE2.3.30.0003)
http://linked.open...iv/cisloPeriodika
  • 17
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  • 65087
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  • RIV/61388971:_____/13:00425635
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  • antibiotics; lincomycin; natural products (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [148CBFD59570]
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  • Chembiochem
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  • 14
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  • Bauer, J.
  • Benada, Oldřich
  • Halada, Petr
  • Kameník, Zdeněk
  • Olšovská, Jana
  • Novotná, Jitka
  • Kadlec, J.
  • Kutejová, Eva
  • Janata, Jiří
  • Najmanová, Lucie
  • Polan, M.
http://linked.open...ain/vavai/riv/wos
  • 000330181300006
issn
  • 1439-4227
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/cbic.201300389
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