About: Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1

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About: Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A Gram-negative bacterium transforming codeine 1a to 14-hydroxycodeine 1c was isolated from the sample of composted wastes of Papaver somniferum deposited in a factory producing poppy seed. Based on 16S ribosomal RNA gene phylogeny, biochemical and morphological properties, the strain was designated as Rhizobium radiobacter R89-1. The bacterium is able to transform 1a into four C-14-hydroxy derivatives of codeine. When used as a whole-cell catalyst, 100% conversion was achieved at concentration of 1a up to 6.0 g/L to 14-hydroxycodeine 1c as a single product. Biohydroxylation of codeine to C-14-hydroxy derivatives, a high tolerance of the strain to 1a and activity with morphine 2a make the biocatalyst promising for pharmaceutical applications. (c) 2012 Elsevier B.V. All rights reserved A Gram-negative bacterium transforming codeine 1a to 14-hydroxycodeine 1c was isolated from the sample of composted wastes of Papaver somniferum deposited in a factory producing poppy seed. Based on 16S ribosomal RNA gene phylogeny, biochemical and morphological properties, the strain was designated as Rhizobium radiobacter R89-1. The bacterium is able to transform 1a into four C-14-hydroxy derivatives of codeine. When used as a whole-cell catalyst, 100% conversion was achieved at concentration of 1a up to 6.0 g/L to 14-hydroxycodeine 1c as a single product. Biohydroxylation of codeine to C-14-hydroxy derivatives, a high tolerance of the strain to 1a and activity with morphine 2a make the biocatalyst promising for pharmaceutical applications. (c) 2012 Elsevier B.V. All rights reserved (en)
Title	Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 (en)
skos:prefLabel	Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1 (en)
skos:notation	RIV/61388971:_____/13:00392590!RIV14-MSM-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(2B08064)
http://linked.open...iv/cisloPeriodika	MAR 2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kyslík, Pavel Štěpánek, Václav Zahradník, Jiří Valešová, Renata Marešová, Helena Kyslíková, Eva Palyzová, Andrea Babiak, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	63577
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/13:00392590
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Biotransformation; codeine; morphine (en)
http://linked.open.../riv/klicoveSlovo	codeine morphine Biotransformation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[EFC9A35EA3E0]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Catalysis B-Enzymatic
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Introduction of producers generating new and modified antibiotics.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	87
http://linked.open...iv/tvurceVysledku	Kyslík, Pavel Štěpánek, Václav Zahradník, Jiří Babiak, Petr Hájíček, J. Kyslíková, Eva Marešová, Helena Palyzová, Andrea Valešová, Renata
http://linked.open...ain/vavai/riv/wos	000314012900001
issn	1381-1177
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molcatb.2012.10.004

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