About: CobB1 deacetylase activity in Streptomyces coelicolor

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Silent information regulators are NAD(+)-dependent enzymes that display differential specificity toward acetylated substrates. This report provides first evidence for deacetylation activity of CobB1 in Streptomyces coelicolor. The protein is highly conserved in streptomycetes. The CobB1 protein catalytically removes the acetyl group from acetylated bovine serum albumin. In the absence of NAD(+) or when NAD(+) was substituted with nicotinamide, deacetylation was stopped. We isolated gene encoding AcetylCoA synthetaseA. The recombinant enzyme produces Acetyl-CoA from acetate. The highest acsA-mRNA level was detected in cells from the exponential phase of growth, and then decreased in transition and stationary phases of growth Silent information regulators are NAD(+)-dependent enzymes that display differential specificity toward acetylated substrates. This report provides first evidence for deacetylation activity of CobB1 in Streptomyces coelicolor. The protein is highly conserved in streptomycetes. The CobB1 protein catalytically removes the acetyl group from acetylated bovine serum albumin. In the absence of NAD(+) or when NAD(+) was substituted with nicotinamide, deacetylation was stopped. We isolated gene encoding AcetylCoA synthetaseA. The recombinant enzyme produces Acetyl-CoA from acetate. The highest acsA-mRNA level was detected in cells from the exponential phase of growth, and then decreased in transition and stationary phases of growth (en)
Title	CobB1 deacetylase activity in Streptomyces coelicolor CobB1 deacetylase activity in Streptomyces coelicolor (en)
skos:prefLabel	CobB1 deacetylase activity in Streptomyces coelicolor CobB1 deacetylase activity in Streptomyces coelicolor (en)
skos:notation	RIV/61388971:_____/12:00377498!RIV13-GA0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/09/0475), P(IAA500110805), Z(AV0Z50110509), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Felsberg, Jürgen Mikulík, Karel Bezoušková, Silvia Šetinová, Dita Stodůlková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	127582
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/12:00377498
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sirtuin; NAD(+)dependent deacetylation activity CobB1; Streptomyces coeliocolor (en)
http://linked.open.../riv/klicoveSlovo	NAD(+)dependent deacetylation activity CobB1 Streptomyces coeliocolor sirtuin
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[196718A84612]
http://linked.open...i/riv/nazevZdroje	Biochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of mechanisms of adipokine autocrine effects on glucose and lipid metabolism Biocomputational prediction of intergenic structures in Actinomyces
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	90
http://linked.open...iv/tvurceVysledku	Zídek, Václav Felsberg, Jürgen Stodůlková, Eva Bezoušková, Silvia Mikulík, Karel Zídková, J. Kudrnáčová, E. Šetinová, Dita
http://linked.open...ain/vavai/riv/wos	000302229800007
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Microorganisms in Research and Biotechnology
issn	0829-8211
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1139/O11-086

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