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Description
  • The current molecular, serological and emphasized mass spectral approaches used in fungal diagnostics are evaluated. An overview of low-molecular weight metabolites that have been used in medical mycology during either in vitro or in vivo experiments is presented. Fungal spores are suggested as a viable source of fungal biomarkers, as conidia inhalation is an important entrance gateway to host infection. In addition to MALDI (Matrix Assisted Laser Desorption/Ionization) typing, an alternative diagnostic method based on the knowledge of specific nonribosomal and other fungal metabolite structures is suggested. This approach can be used in fungal mixture analysis and represents a similar benefit to what we have learned from proteomics: going from peptide mapping to peptide sequencing could give better identification rates
  • The current molecular, serological and emphasized mass spectral approaches used in fungal diagnostics are evaluated. An overview of low-molecular weight metabolites that have been used in medical mycology during either in vitro or in vivo experiments is presented. Fungal spores are suggested as a viable source of fungal biomarkers, as conidia inhalation is an important entrance gateway to host infection. In addition to MALDI (Matrix Assisted Laser Desorption/Ionization) typing, an alternative diagnostic method based on the knowledge of specific nonribosomal and other fungal metabolite structures is suggested. This approach can be used in fungal mixture analysis and represents a similar benefit to what we have learned from proteomics: going from peptide mapping to peptide sequencing could give better identification rates (en)
Title
  • Fungal Metabolites for Microorganism Classification by Mass Spectrometry
  • Fungal Metabolites for Microorganism Classification by Mass Spectrometry (en)
skos:prefLabel
  • Fungal Metabolites for Microorganism Classification by Mass Spectrometry
  • Fungal Metabolites for Microorganism Classification by Mass Spectrometry (en)
skos:notation
  • RIV/61388971:_____/11:00374062!RIV12-AV0-61388971
http://linked.open...avai/riv/aktivita
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  • P(LC07017), Z(AV0Z50200510)
http://linked.open...vai/riv/dodaniDat
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  • 200561
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  • RIV/61388971:_____/11:00374062
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  • Microorganism; mass spectrometry; biomarker (en)
http://linked.open.../riv/klicoveSlovo
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  • [42BAC4CB530C]
http://linked.open...i/riv/mistoVydani
  • Washington DC
http://linked.open...i/riv/nazevZdroje
  • Rapid Characterization of Microorganisms by Mass Spectrometry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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  • Lemr, Karel
  • Havlíček, Vladimír
http://linked.open...n/vavai/riv/zamer
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/bk-2011-1065
http://purl.org/ne...btex#hasPublisher
  • American Chemical Society
https://schema.org/isbn
  • 978-0-8412-2612-8
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