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  • Knowledge of the spatial distribution of lipids in the intraocular lens is important for understanding the physiology and biochemistry of this unique tissue and for gaining a better insight into the mechanisms underlying diseases of the lens. Following our previous study showing the spatial distribution of sphingolipids in the porcine lens, the current study used ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS) to provide the whole lipidome of porcine lens and these studies were supplemented by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) of the lens using ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) to determine the spatial distribution of glycerophospholipids
  • Knowledge of the spatial distribution of lipids in the intraocular lens is important for understanding the physiology and biochemistry of this unique tissue and for gaining a better insight into the mechanisms underlying diseases of the lens. Following our previous study showing the spatial distribution of sphingolipids in the porcine lens, the current study used ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS) to provide the whole lipidome of porcine lens and these studies were supplemented by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) of the lens using ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) to determine the spatial distribution of glycerophospholipids (en)
Title
  • Spatial Distribution of Glycerophospholipids in the Ocular Lens
  • Spatial Distribution of Glycerophospholipids in the Ocular Lens (en)
skos:prefLabel
  • Spatial Distribution of Glycerophospholipids in the Ocular Lens
  • Spatial Distribution of Glycerophospholipids in the Ocular Lens (en)
skos:notation
  • RIV/61388971:_____/11:00371571!RIV12-AV0-61388971
http://linked.open...avai/riv/aktivita
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  • P(GPP206/10/P018), P(LC07017), Z(AV0Z50200510)
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  • 4
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  • 231181
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  • RIV/61388971:_____/11:00371571
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  • MASS SPECTROMETRY; MEMBRANE-PROTEINS; ALPHA-CRYSTALLIN (en)
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  • US - Spojené státy americké
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  • [04D5429D53B5]
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  • PLoS ONE
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  • 6
http://linked.open...iv/tvurceVysledku
  • Novák, Petr
  • Havlíček, Vladimír
  • Volný, Michael
  • Strohalm, Martin
  • Holopainen, J.
  • Hyötyläinen, T.
  • Kostiainen, R.
  • Pól, Jaroslav
  • Vidová, Veronika
  • Wiedmer, S. K.
http://linked.open...ain/vavai/riv/wos
  • 000290024700172
http://linked.open...n/vavai/riv/zamer
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0019441
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