About: Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp asukaensis

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About: Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp asukaensis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Production of minor asukamycin congeners and its new derivatives by combination of targeted genetic manipulations with specific precursor feeding in the producer of asukamycin, Streptomyces nodosus ssp. asukaensis. Structural variations of manumycins lie only in the diverse initiation of the 'upper' polyketide chain. Inactivation of the gene involved in the biosynthesis of cyclohexanecarboxylic acid (CHC) turned off the production of asukamycin in the mutant strain and allowed an increased production of other manumycins with the branched end of the upper chain Production of minor asukamycin congeners and its new derivatives by combination of targeted genetic manipulations with specific precursor feeding in the producer of asukamycin, Streptomyces nodosus ssp. asukaensis. Structural variations of manumycins lie only in the diverse initiation of the 'upper' polyketide chain. Inactivation of the gene involved in the biosynthesis of cyclohexanecarboxylic acid (CHC) turned off the production of asukamycin in the mutant strain and allowed an increased production of other manumycins with the branched end of the upper chain (en)
Title	Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp asukaensis Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp asukaensis (en)
skos:prefLabel	Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp asukaensis Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp asukaensis (en)
skos:notation	RIV/61388971:_____/11:00370935!RIV12-AV0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06154), P(IAA600660607), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Sedmera, Petr Petříček, Miroslav Petříčková, Kateřina Pospíšil, Stanislav Halada, Petr Olšovská, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	196476
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/11:00370935
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	analogue; asukamycin; manumycin antibiotics (en)
http://linked.open.../riv/klicoveSlovo	analogue asukamycin manumycin antibiotics
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3C1564FBAAB8]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Microbiology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification and isolation of new secondary metabolites with anti-inflammatory and anti-apoptotic features from actinomycetes. Gene screening of actinomycetes producing new substances with potential therapeutic applications to modulate immune mechanisms.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	111
http://linked.open...iv/tvurceVysledku	Halada, Petr Olšovská, Jana Pospíšil, Stanislav Petříček, Miroslav Petříčková, Kateřina Sedmera, Petr
http://linked.open...ain/vavai/riv/wos	000297020900009
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1364-5072
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1365-2672.2011.05132.x

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