About: Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments     Goto   Sponge   NotDistinct   Permalink

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  • Traditional tissue-sectioning techniques for histological samples utilize various embedding media to stabilize the tissue on a sectioning target and to provide a smooth cutting surface. Due to the ion suppression effect in MALDI ionization and number of background peaks in the low-mass region, these media are not suitable for mass spectrometry imaging (MSI) experiments. To overcome this, droplets of water are often used to mount the tissue on a sectioning target, but the ice block formed around the tissue does not provide a good support for sectioning of fragile samples. In this work, we propose a novel embedding media, compatible with MALDI ionization and MSI experiments, based on poly[N-(2-hydroxypropyl)methacrylamide] (pHPMA)
  • Traditional tissue-sectioning techniques for histological samples utilize various embedding media to stabilize the tissue on a sectioning target and to provide a smooth cutting surface. Due to the ion suppression effect in MALDI ionization and number of background peaks in the low-mass region, these media are not suitable for mass spectrometry imaging (MSI) experiments. To overcome this, droplets of water are often used to mount the tissue on a sectioning target, but the ice block formed around the tissue does not provide a good support for sectioning of fragile samples. In this work, we propose a novel embedding media, compatible with MALDI ionization and MSI experiments, based on poly[N-(2-hydroxypropyl)methacrylamide] (pHPMA) (en)
Title
  • Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments
  • Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments (en)
skos:prefLabel
  • Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments
  • Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments (en)
skos:notation
  • RIV/61388971:_____/11:00370783!RIV12-AV0-61388971
http://linked.open...avai/riv/aktivita
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  • I, P(GPP206/10/P018), P(IAAX00500803), P(LC545), S, Z(AV0Z40500505), Z(AV0Z40550506), Z(AV0Z50200510)
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  • 13
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  • 221269
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  • RIV/61388971:_____/11:00370783
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  • SECTIONS; NEUROPEPTIDES; PEPTIDES (en)
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  • US - Spojené státy americké
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  • [B17FE88D7CFB]
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  • Analytical Chemistry
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  • 83
http://linked.open...iv/tvurceVysledku
  • Novák, Petr
  • Strohalm, Jiří
  • Ulbrich, Karel
  • Havlíček, Vladimír
  • Krásný, Lukáš
  • Kaftan, Filip
  • Volný, Michael
  • Strohalm, Martin
http://linked.open...ain/vavai/riv/wos
  • 000292280900062
http://linked.open...n/vavai/riv/zamer
issn
  • 0003-2700
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/ac2011679
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