About: Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied (en)
Title	Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors (en)
skos:prefLabel	Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors (en)
skos:notation	RIV/61388971:_____/11:00366522!RIV12-AV0-61388971
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA303/09/0477), P(GD305/09/H008), P(GP203/09/P024), S, Z(AV0Z50200510), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Drozdová, Anna Kuzma, Marek Adámek, David Krupová, Monika Weignerová, Lenka Slámová, Kristýna Bezouška, Karel Bojarová, Pavla Křen, Vladimír Křenek, Karel Pelantová, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	197799
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/11:00366522
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	beta-N-Acetylhexosaminidase; alactosyltransferase; Enzymatic glycosylation (en)
http://linked.open.../riv/klicoveSlovo	Enzymatic glycosylation alactosyltransferase beta-N-Acetylhexosaminidase
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[A8591FAF158C]
http://linked.open...i/riv/nazevZdroje	Carbohydrate Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects Glycomic and proteomic analysis of the molecular mechanisms of elimination of clinically relevant tumors by killer cells of the immune system Synthesis of immunoactive glycosides by beta-N-acetylhexosaminidases
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	346
http://linked.open...iv/tvurceVysledku	Adámek, David Bezouška, Karel Bojarová, Pavla Elling, L. Křen, Vladimír Křenek, Karel Kuzma, Marek Pelantová, Helena Slámová, Kristýna Christensen, H. Drozdová, Anna Hensen, B. Jensen, H. H. Krupová, Monika Weignerová, Lenka
http://linked.open...ain/vavai/riv/wos	000292852100029
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0008-6215
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.carres.2011.04.043

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