About: Gliadin fragments promote migration of dendritic cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Gliadin fragments promote migration of dendritic cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study provides a new insight into pathogenic features of gliadin fragments by demonstrating their ability to promote DC migration, which is a prerequisite for efficient priming of naive T cells, contributing to celiac disease pathology. In genetically predisposed individuals, ingestion of wheat gliadin provokes a T-cell-mediated enteropathy, celiac disease. Gliadin fragments were previously reported to induce phenotypic maturation and Th1 cytokine production by human dendritic cells (DCs) and to boost their capacity to stimulate allogeneic T cells. Here, we monitor the effects of gliadin on migratory capacities of DCs. Using transwell assays, we show that gliadin peptic digest stimulates migration of human DCs and their chemotactic responsiveness to the lymph node-homing chemokines CCL19 and CCL21 This study provides a new insight into pathogenic features of gliadin fragments by demonstrating their ability to promote DC migration, which is a prerequisite for efficient priming of naive T cells, contributing to celiac disease pathology. In genetically predisposed individuals, ingestion of wheat gliadin provokes a T-cell-mediated enteropathy, celiac disease. Gliadin fragments were previously reported to induce phenotypic maturation and Th1 cytokine production by human dendritic cells (DCs) and to boost their capacity to stimulate allogeneic T cells. Here, we monitor the effects of gliadin on migratory capacities of DCs. Using transwell assays, we show that gliadin peptic digest stimulates migration of human DCs and their chemotactic responsiveness to the lymph node-homing chemokines CCL19 and CCL21 (en)
Title	Gliadin fragments promote migration of dendritic cells Gliadin fragments promote migration of dendritic cells (en)
skos:prefLabel	Gliadin fragments promote migration of dendritic cells Gliadin fragments promote migration of dendritic cells (en)
skos:notation	RIV/61388971:_____/11:00361617!RIV12-AV0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/0414), P(GA310/08/0447), P(GD310/08/H077), P(IAA500200801), P(IAA500200914), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Tučková, Ludmila Cinová, Jana Šebo, Peter Palová-Jelínková, Lenka Kamanová, Jana Chládková, Barbara
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	201313
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/11:00361617
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	celiac disease; gliadin; dendritic cell (en)
http://linked.open.../riv/klicoveSlovo	gliadin celiac disease dendritic cell
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[18915BBAE74A]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular and Molecular Medicine
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms underlying modulation of immune cell functions by cAMP Molecular mechanism of adenylate cyclase toxin penetration into phagocytes The role of innate and adaptive immunity in development of gluten-sensitive entheropathy Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches Food allergy to wheat proteins
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Cinová, Jana Tučková, Ludmila Chládková, Barbara Kamanová, Jana Palová-Jelínková, Lenka Šebo, Peter
http://linked.open...ain/vavai/riv/wos	000290312700019
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1582-1838
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1582-4934.2010.01066.x

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software