About: Fragmentation of Human Erythrocyte Actin following Exposure to Hypoxia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In a comparative study on erythrocytes (RBCs) drawn from mountaineers before and after a high-altitude stay, we observed that upon returning to sea level, their RBCs displayed a senescent-like phenotype as indicated by their density and the partial loss of membrane proteins which are shed by ageing RBCs. The aim of this study was to investigate possible changes in the membrane skeleton of these RBCs and to compare them with pathological RBCs. We analysed the proteins of RBC ghosts obtained from our subjects before and after returning to sea level by two-dimensional electrophoresis and mass spectrometry. We observed lower expression and fragmentation of -actin after exposure to hypoxia. This suggested an alteration in membrane skeleton structure, which was confirmed by -actin release in cell lysates during ghost preparation In a comparative study on erythrocytes (RBCs) drawn from mountaineers before and after a high-altitude stay, we observed that upon returning to sea level, their RBCs displayed a senescent-like phenotype as indicated by their density and the partial loss of membrane proteins which are shed by ageing RBCs. The aim of this study was to investigate possible changes in the membrane skeleton of these RBCs and to compare them with pathological RBCs. We analysed the proteins of RBC ghosts obtained from our subjects before and after returning to sea level by two-dimensional electrophoresis and mass spectrometry. We observed lower expression and fragmentation of -actin after exposure to hypoxia. This suggested an alteration in membrane skeleton structure, which was confirmed by -actin release in cell lysates during ghost preparation (en)
Title	Fragmentation of Human Erythrocyte Actin following Exposure to Hypoxia Fragmentation of Human Erythrocyte Actin following Exposure to Hypoxia (en)
skos:prefLabel	Fragmentation of Human Erythrocyte Actin following Exposure to Hypoxia Fragmentation of Human Erythrocyte Actin following Exposure to Hypoxia (en)
skos:notation	RIV/61388971:_____/10:00355472!RIV11-AV0-61388971
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bezouška, Karel Pompach, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	259717
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00355472
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	beta-Actin; Erythrocytes; Hypoxia (en)
http://linked.open.../riv/klicoveSlovo	Erythrocytes Hypoxia beta-Actin
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[133D2CC33F10]
http://linked.open...i/riv/nazevZdroje	Acta Haematologica
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	123
http://linked.open...iv/tvurceVysledku	Bezouška, Karel Pompach, Petr Antonutto, G. Cosulich, M. E. Pistarino, E. Risso, A. Santamaria, B.
http://linked.open...ain/vavai/riv/wos	000272340700002
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0001-5792
number of pages	8 (xsd:int)

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