About: Biochemical and Genetic Insights into Asukamycin Biosynthesis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Asukamycin, a member of the manumycin family metabolites, is an antimicrobial and potential antitumor agent isolated from Streptomyces nodosus subsp. asukaensis. The entire asukamycin biosynthetic gene cluster was cloned, assembled, and expressed heterologously in Streptomyces lividans. Bioinformatic analysis and mutagenesis studies elucidated the biosynthetic pathway at the genetic and biochemical level. Four gene sets, asuA–D, govern the formation and assembly of the asukamycin building blocks: a 3-amino-4-hydroxybenzoic acid core component, a cyclohexane ring, two triene polyketide chains, and a 2-amino-3-hydroxycyclopent-2-enone moiety to form the intermediate protoasukamycin Asukamycin, a member of the manumycin family metabolites, is an antimicrobial and potential antitumor agent isolated from Streptomyces nodosus subsp. asukaensis. The entire asukamycin biosynthetic gene cluster was cloned, assembled, and expressed heterologously in Streptomyces lividans. Bioinformatic analysis and mutagenesis studies elucidated the biosynthetic pathway at the genetic and biochemical level. Four gene sets, asuA–D, govern the formation and assembly of the asukamycin building blocks: a 3-amino-4-hydroxybenzoic acid core component, a cyclohexane ring, two triene polyketide chains, and a 2-amino-3-hydroxycyclopent-2-enone moiety to form the intermediate protoasukamycin (en)
Title	Biochemical and Genetic Insights into Asukamycin Biosynthesis Biochemical and Genetic Insights into Asukamycin Biosynthesis (en)
skos:prefLabel	Biochemical and Genetic Insights into Asukamycin Biosynthesis Biochemical and Genetic Insights into Asukamycin Biosynthesis (en)
skos:notation	RIV/61388971:_____/10:00348161!RIV11-MSM-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06154), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	32
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Petříček, Miroslav Petříčková, Kateřina Pospíšil, Stanislav Škanta, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	248824
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00348161
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NODOSUS SUBSP ASUKAENSIS; FATTY-ACID SYNTHASE; CRYSTAL-STRUCTURE (en)
http://linked.open.../riv/klicoveSlovo	CRYSTAL-STRUCTURE FATTY-ACID SYNTHASE NODOSUS SUBSP ASUKAENSIS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7EEDD65C76B3]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification and isolation of new secondary metabolites with anti-inflammatory and anti-apoptotic features from actinomycetes.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	285
http://linked.open...iv/tvurceVysledku	Pospíšil, Stanislav Petříček, Miroslav Petříčková, Kateřina Yang, Y. Škanta, František Chen, Ch.-Y. Floss, H. G. Rui, Z. Tsai, S.-F. Yu, T.-W.
http://linked.open...ain/vavai/riv/wos	000280542100064
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0021-9258
number of pages	10 (xsd:int)

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