About: Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells     Goto   Sponge   NotDistinct   Permalink

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  • Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
  • Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host. (en)
Title
  • Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
  • Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells (en)
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  • Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
  • Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells (en)
skos:notation
  • RIV/61388971:_____/10:00347290!RIV11-AV0-61388971
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA600960811), Z(AV0Z50200510), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 265078
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/10:00347290
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Tick-borne encephalitis virus; Dendritic cell; Tick saliva; Ixodes ricinus (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [6937006C5CDE]
http://linked.open...i/riv/nazevZdroje
  • Microbes and Infection
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Kopecký, Jan
  • Fialová, Anna
  • Cimburek, Zdeněk
  • Iezzi, G.
http://linked.open...ain/vavai/riv/wos
  • 000279561500010
http://linked.open...n/vavai/riv/zamer
issn
  • 1286-4579
number of pages
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