About: Glycine-rich loop of mitochondrial processing peptidase α-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tryptophan fluorescence measurements were used to characterize the local dynamics of the highly conserved glycine-rich loop (GRL) of the mitochondrial processing peptidase (MPP) subunit in the presence of the substrate precursor. Reporter tryptophan residue was introduced into the GRL of the yeast MPP (Y299W) or at a proximal site (Y303W). Timeresolved and steady-state fluorescence spectroscopy demonstrated that for Trp299, the primary contact with the yeast malate dehydrogenase precursor evokes a change of the local GRL mobility. Moreover, time-resolved measurements showed that a functionless MPP with a single-residue deletion in the loop (Y303W/G292) is defective particularly in the primary contact with substrate Tryptophan fluorescence measurements were used to characterize the local dynamics of the highly conserved glycine-rich loop (GRL) of the mitochondrial processing peptidase (MPP) subunit in the presence of the substrate precursor. Reporter tryptophan residue was introduced into the GRL of the yeast MPP (Y299W) or at a proximal site (Y303W). Timeresolved and steady-state fluorescence spectroscopy demonstrated that for Trp299, the primary contact with the yeast malate dehydrogenase precursor evokes a change of the local GRL mobility. Moreover, time-resolved measurements showed that a functionless MPP with a single-residue deletion in the loop (Y303W/G292) is defective particularly in the primary contact with substrate (en)
Title	Glycine-rich loop of mitochondrial processing peptidase α-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20 Glycine-rich loop of mitochondrial processing peptidase α-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20 (en)
skos:prefLabel	Glycine-rich loop of mitochondrial processing peptidase α-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20 Glycine-rich loop of mitochondrial processing peptidase α-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20 (en)
skos:notation	RIV/61388971:_____/10:00340832!RIV11-AV0-61388971
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(IAA501110631), S, Z(AV0Z50200510), Z(MSM0021620835), Z(MSM6198959215), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Janata, Jiří Kučera, Tomáš Matušková, Anna Holá, Klára Parkhomenko, Natalia
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	260849
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00340832
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondrial processing peptidase; presequence; substrate recognition (en)
http://linked.open.../riv/klicoveSlovo	mitochondrial processing peptidase presequence substrate recognition
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F11EB08848FF]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Biology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Evolution and biogenesis of mitochondria-related organelles: hydrogenosomes and mitosomes
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	396
http://linked.open...iv/tvurceVysledku	Kučera, Tomáš Kubala, M. Heřman, P. Otyepka, M. Večeř, J. Matušková, Anna Janata, Jiří Dvořáková-Holá, Klára Parkhomenko, Natalia Kutejová, E.
http://linked.open...ain/vavai/riv/wos	000275691500002
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Fyzika molekulárních, makromolekulárních a biologických systémů Variabilita složek a interakcí v rostlinném patosystému a vliv faktorů prostředí na jejich projev Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0022-2836
number of pages	14 (xsd:int)

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