About: Genetic Control of Biosynthesis of Secondary Metabolites

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About: Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lincomycin and its derivatives are potent antibiotics used in human and veterinary medicine. Lincomycin molecule is composed of two subunits, methylthiolincosamide (MTL) and methylproline linked by an amide bond. The gene cluster of Streptomyces lincolnensis controlling lincomycin biosynthesis contains 29 ORFs with putative biosynthetic/regulatory (lmb) and resistance (lmr) functions. Six ORFs (lmbA, B1, B2, W, X, Y) were found to have their counterparts among genes controlling biosynthesis of anthramycin sharing with lincomycin the initial reactions of biosynthesis of proline derivatives. Functions of LmbB1 and LmbB2 proteins were demonstrated in vitro; by gene inactivation analysis lmbA, X, W genes were confirmed to be included in propylproline biosynthesis Lincomycin and its derivatives are potent antibiotics used in human and veterinary medicine. Lincomycin molecule is composed of two subunits, methylthiolincosamide (MTL) and methylproline linked by an amide bond. The gene cluster of Streptomyces lincolnensis controlling lincomycin biosynthesis contains 29 ORFs with putative biosynthetic/regulatory (lmb) and resistance (lmr) functions. Six ORFs (lmbA, B1, B2, W, X, Y) were found to have their counterparts among genes controlling biosynthesis of anthramycin sharing with lincomycin the initial reactions of biosynthesis of proline derivatives. Functions of LmbB1 and LmbB2 proteins were demonstrated in vitro; by gene inactivation analysis lmbA, X, W genes were confirmed to be included in propylproline biosynthesis (en)
Title	Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples (en)
skos:prefLabel	Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples (en)
skos:notation	RIV/61388971:_____/09:00340932!RIV10-AV0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500200810), Z(AV0Z50200510)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Smutná, Yvona Novotná, Jitka Janata, Jiří Spížek, Jaroslav Kadlčík, Stanislav Ulanová, Dana Najmanová, Lucie Koběrská, Markéta Olšovská, Jana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	316148
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/09:00340932
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lincomycin (en)
http://linked.open.../riv/klicoveSlovo	lincomycin
http://linked.open...ontrolniKodProRIV	[4C702F2CDF21]
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Genes determining critical steps in designing the producers of hybrid lincosamide antibiotics
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Olšovská, Jana Novotná, Jitka Janata, Jiří Kadlčík, Stanislav Koběrská, Markéta Najmanová, Lucie Ulanová, Dana Spížek, Jaroslav Smutná, Yvona
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology

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