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rdf:type
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Description
| - Hepcidin is a major regulator of iron metabolism. Hepcidin-based therapeutics/diagnostics could play roles in hematology in the future, and thus, hepcidin transport is crucial to understand. In this study, we identify alpha2-macroglobulin (alpha2-M) as the specific hepcidin-binding molecule in blood. Interaction of 125I-hepcidin with alpha2-M was identified using fractionation of plasma proteins followed by native gradient polyacrylamide gel electrophoresis and mass spectrometry. Hepcidin binding to nonactivated alpha2-M displays high affinity , whereas hepcidin binding to albumin was nonspecific and displayed nonsaturable kinetics
- Hepcidin is a major regulator of iron metabolism. Hepcidin-based therapeutics/diagnostics could play roles in hematology in the future, and thus, hepcidin transport is crucial to understand. In this study, we identify alpha2-macroglobulin (alpha2-M) as the specific hepcidin-binding molecule in blood. Interaction of 125I-hepcidin with alpha2-M was identified using fractionation of plasma proteins followed by native gradient polyacrylamide gel electrophoresis and mass spectrometry. Hepcidin binding to nonactivated alpha2-M displays high affinity , whereas hepcidin binding to albumin was nonspecific and displayed nonsaturable kinetics (en)
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Title
| - Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin
- Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin (en)
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skos:prefLabel
| - Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin
- Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin (en)
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skos:notation
| - RIV/61388971:_____/09:00338673!RIV10-MSM-61388971
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA204/07/0830), P(GA305/09/1390), P(GD204/03/H066), P(LC06044), P(LC07017), P(NR8317), P(NR8930), P(NS10300), Z(AV0Z50200510), Z(MSM0021620806), Z(MSM0021620858), Z(MZ0UHKT2005)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/09:00338673
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - RECEPTOR-RELATED PROTEIN; GROWTH-FACTOR-BETA; BINDING-PROTEIN (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Halada, Petr
- Petrák, J.
- Kuželová, K.
- Rahmanto, Y. S.
- Hrdý, I.
- Richardson, D. R.
- Becker, E.
- Ponka, P.
- Huang, M. L.-H.
- Kuchel, P. W.
- Pešlová, G.
- Soe-Lin, S.
- Vyoral, D.
- Šuták, R.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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