About: Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hepcidin is a major regulator of iron metabolism. Hepcidin-based therapeutics/diagnostics could play roles in hematology in the future, and thus, hepcidin transport is crucial to understand. In this study, we identify alpha2-macroglobulin (alpha2-M) as the specific hepcidin-binding molecule in blood. Interaction of 125I-hepcidin with alpha2-M was identified using fractionation of plasma proteins followed by native gradient polyacrylamide gel electrophoresis and mass spectrometry. Hepcidin binding to nonactivated alpha2-M displays high affinity , whereas hepcidin binding to albumin was nonspecific and displayed nonsaturable kinetics Hepcidin is a major regulator of iron metabolism. Hepcidin-based therapeutics/diagnostics could play roles in hematology in the future, and thus, hepcidin transport is crucial to understand. In this study, we identify alpha2-macroglobulin (alpha2-M) as the specific hepcidin-binding molecule in blood. Interaction of 125I-hepcidin with alpha2-M was identified using fractionation of plasma proteins followed by native gradient polyacrylamide gel electrophoresis and mass spectrometry. Hepcidin binding to nonactivated alpha2-M displays high affinity , whereas hepcidin binding to albumin was nonspecific and displayed nonsaturable kinetics (en)
Title	Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin (en)
skos:prefLabel	Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin (en)
skos:notation	RIV/61388971:_____/09:00338673!RIV10-MSM-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0830), P(GA305/09/1390), P(GD204/03/H066), P(LC06044), P(LC07017), P(NR8317), P(NR8930), P(NS10300), Z(AV0Z50200510), Z(MSM0021620806), Z(MSM0021620858), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Halada, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	317000
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/09:00338673
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RECEPTOR-RELATED PROTEIN; GROWTH-FACTOR-BETA; BINDING-PROTEIN (en)
http://linked.open.../riv/klicoveSlovo	BINDING-PROTEIN GROWTH-FACTOR-BETA RECEPTOR-RELATED PROTEIN
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[55FFC8AD03C9]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of cell interactions Regulatory mechanisms of growth and apoptosis of primary leukemia progenitor/stem cells. Proteomic diagnosis of onkologic disaeses in gynecology Center for Experimental Hematology Oncoproteomics Centre Therapeutic and diagnostic potential of hepcidin. Investigation of metabolic mechanisms of heart failure progression in an experimental model Iron metabolism and cellular cytoskeleton: defining a new role for MRCK?
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	113
http://linked.open...iv/tvurceVysledku	Halada, Petr Petrák, J. Kuželová, K. Rahmanto, Y. S. Hrdý, I. Richardson, D. R. Becker, E. Ponka, P. Huang, M. L.-H. Kuchel, P. W. Pešlová, G. Soe-Lin, S. Vyoral, D. Šuták, R.
http://linked.open...ain/vavai/riv/wos	000267147100027
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Signaling and cellular response mechanisms Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0006-4971
number of pages	12 (xsd:int)

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