About: Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method

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About: Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The kinetic method has been applied for determination of d-Phe/l-Phe enantiomeric ratio. Discrimination of enantiomers was inferred from product ion mass spectra of trimeric cluster ions containing the analyte (l,d-Phe), Cu2 as a central metal and l-Trp as a chiral reference ligand. Unsatisfactory quantitative results achieved on an ion trapwere rationalized by high-resolution mass spectrometry. The formation of Mg2-containing cluster isobaric to trimeric cluster [Cu(l-Trp)2Phe] was observed. Interference like this was identified as a possible reason for deterioration of quantitative low-resolution mass spectrometric analyses of real-world samples based on the kinetic method. Cation-exchangerwas used for easy removal of magnesium from a sample and improvement of quantitation. Chiral dependence of formation of the Cu2 containing trimeric clusterwas also observed. Heterochiral diastereoisomeric ions were created less effectively The kinetic method has been applied for determination of d-Phe/l-Phe enantiomeric ratio. Discrimination of enantiomers was inferred from product ion mass spectra of trimeric cluster ions containing the analyte (l,d-Phe), Cu2 as a central metal and l-Trp as a chiral reference ligand. Unsatisfactory quantitative results achieved on an ion trapwere rationalized by high-resolution mass spectrometry. The formation of Mg2-containing cluster isobaric to trimeric cluster [Cu(l-Trp)2Phe] was observed. Interference like this was identified as a possible reason for deterioration of quantitative low-resolution mass spectrometric analyses of real-world samples based on the kinetic method. Cation-exchangerwas used for easy removal of magnesium from a sample and improvement of quantitation. Chiral dependence of formation of the Cu2 containing trimeric clusterwas also observed. Heterochiral diastereoisomeric ions were created less effectively (en)
Title	Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method (en)
skos:prefLabel	Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method (en)
skos:notation	RIV/61388971:_____/09:00328370!RIV10-MSM-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/07/0765), P(LC07017), Z(AV0Z50200510), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lemr, Karel Havlíček, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	324332
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/09:00328370
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	enantiomeric dicrimination; kinetic method; mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry kinetic method enantiomeric dicrimination
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[4BB9B8F0E622]
http://linked.open...i/riv/nazevZdroje	International Journal of Mass Spectrometry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Oncoproteomics Centre Analysis of isomers by mass spectrometry and kinetic method
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	280
http://linked.open...iv/tvurceVysledku	Lemr, Karel Havlíček, Vladimír Bednář, P. Ranc, V.
http://linked.open...ain/vavai/riv/wos	000263195500034
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1387-3806
number of pages	5 (xsd:int)

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