| Attributes | Values |
|---|
| rdf:type
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| Description
| - Pomocí kinetické metody a elektrospreje byla odladěna kvalitativní a kvantivativní stanovení tří významných farmaceutických substancí: dihydroxyphenylalaninu (DOPA), ephedrinu and ibuprofenu. Při tvorbě ternárního komplexu, jehož disociace byla použita k odlišení D a L-forem, byla použita dvojmocná měď a L-fenylalanin jako chirální ligand. Dále byl postaven iontový zdroj, který pracuje na principu desorpčního nanoelektrospreje. Na něm byla enantioselektivní stanovení výše uvedených látek provedena. Bylo demonstrováno, že stanovení lze provést i z lidské krve. Uvedený postup může být použit k chirální analýze léčiv obecně (cs)
- A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 μL samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment
- A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 μL samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment (en)
|
| Title
| - Nano-desorption electrospray and kinetic method in chiral analysis of clinical samples
- Nano-desorption electrospray and kinetic method in chiral analysis of clinical samples (en)
- Desorpční nanoelektrosprej a kinetická metoda v chirální analýze klinických vzorků (cs)
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| skos:prefLabel
| - Nano-desorption electrospray and kinetic method in chiral analysis of clinical samples
- Nano-desorption electrospray and kinetic method in chiral analysis of clinical samples (en)
- Desorpční nanoelektrosprej a kinetická metoda v chirální analýze klinických vzorků (cs)
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| skos:notation
| - RIV/61388971:_____/08:00320962!RIV09-AV0-61388971
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA203/07/0765), P(LC545), Z(AV0Z50200510)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/08:00320962
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - nano-desorption electrospray; mass spectrometry; kinetic method (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - European Journal of Mass Spectrometry
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Lemr, Karel
- Havlíček, Vladimír
- Bednář, P.
- Ranc, V.
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
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