| Attributes | Values |
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| rdf:type
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| Description
| - Mitochondrial processing peptidases are heterodimeric enzymes (a/bMPP) that play an essential role in mitochondrial biogenesis by recognizing and cleaving the targeting presequences of nuclear-encoded mitochondrial proteins. The two subunits are paralogues that probably evolved by duplication of a gene for a monomeric metallopeptidase from the endosymbiotic ancestor of mitochondria. Here, we characterize the MPP-like proteins from two important human parasites that contain highly reduced versions of mitochondria, the mitosomes of Giardia intestinalis and the hydrogenosomes of Trichomonas vaginalis. Our biochemical characterization of recombinant proteins showed that, contrary to a recent report, the Trichomonas processing peptidase functions efficiently as an a/b heterodimer
- Mitochondrial processing peptidases are heterodimeric enzymes (a/bMPP) that play an essential role in mitochondrial biogenesis by recognizing and cleaving the targeting presequences of nuclear-encoded mitochondrial proteins. The two subunits are paralogues that probably evolved by duplication of a gene for a monomeric metallopeptidase from the endosymbiotic ancestor of mitochondria. Here, we characterize the MPP-like proteins from two important human parasites that contain highly reduced versions of mitochondria, the mitosomes of Giardia intestinalis and the hydrogenosomes of Trichomonas vaginalis. Our biochemical characterization of recombinant proteins showed that, contrary to a recent report, the Trichomonas processing peptidase functions efficiently as an a/b heterodimer (en)
- Mitochondriální procesující peptidasy jsou heterodimerní enzymy (a/bMPP), které hrají klíčovou roli v biogenezi mitochondrií tím, že rozpoznávají a odštěpují signální směrovací sekvence mitochondriálních proteinů kódovaných jadernými geny. Obě podjednotky jsou paralogní a vznikly pravděpodobně duplikací genu monomerní metalopeptidasy endosymbiotického předka mitochondrie. Zde jsme charakterizovali MPP-like proteiny ze dvou významných lidských parazitů, kteří obsahují velmi redukované formy mitochondrií – mitosomy z Giardia intestinalis a hydrogenosomy z Trichomonas vaginalis (cs)
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| Title
| - Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis
- Reduktivní evoluce mitochondriálních procesujících peptidas jednobuněčných parazitů Trichomonas vaginalis a Giardia intestinalis (cs)
- Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis (en)
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| skos:prefLabel
| - Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis
- Reduktivní evoluce mitochondriálních procesujících peptidas jednobuněčných parazitů Trichomonas vaginalis a Giardia intestinalis (cs)
- Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis (en)
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| skos:notation
| - RIV/61388971:_____/08:00320319!RIV09-AV0-61388971
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(IAA501110631), P(LC07032), Z(AV0Z50200510), Z(MSM0021620858)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/08:00320319
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - peptidases; mitochondria; human parasites (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kučera, Tomáš
- Novotný, M.
- Matušková, Anna
- Harris, S. R.
- Janata, Jiří
- Tachezy, J.
- Hrdý, I.
- Kutejová, E.
- Embley, T. M.
- Hirt, R. P.
- Horváthová, L.
- Šmíd, O.
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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