| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Caenorhabditis elegant má spoustu genů kódujících jaderné hormonální receptory. Pomocí dvourozměrné kapalinové chromatografie jsme srovnali typ divoký versus nhr-40 mutantní. France, které se vzájemně lišily, byly analyzovány pomocí hmotnostní spektrometrie. Identifikované proteiny mají svou roli v metabolismu a svalech. Získaná data naznačují, že nhr-40 má funkci v koordinaci metabolismu a vývoji svalu (cs)
- Caenorhabditis elegans has an unexpectedly large number (284) of genes encoding nuclear hormone receptors, most of which are nematode-specific and are of unknown function. We have exploited comparative two-dimensional chromatography of synchronized cultures of wild type C. elegans larvae and a mutant in nhr-40 to determine if proteomic approaches will provide additional insight into gene function. Chromatofocusing, followed by reversed-phase chromatography and mass spectrometry, identified altered chromatographic patterns for a set of proteins, many of which function in muscle and metabolism. Prompted by the proteomic analysis, we find that the penetrance of the developmental phenotypes in the mutant is enhanced at low temperatures and by food restriction. The combination of our phenotypic and proteomic analysis strongly suggests that NHR-40 provides a link between metabolism and muscle development
- Caenorhabditis elegans has an unexpectedly large number (284) of genes encoding nuclear hormone receptors, most of which are nematode-specific and are of unknown function. We have exploited comparative two-dimensional chromatography of synchronized cultures of wild type C. elegans larvae and a mutant in nhr-40 to determine if proteomic approaches will provide additional insight into gene function. Chromatofocusing, followed by reversed-phase chromatography and mass spectrometry, identified altered chromatographic patterns for a set of proteins, many of which function in muscle and metabolism. Prompted by the proteomic analysis, we find that the penetrance of the developmental phenotypes in the mutant is enhanced at low temperatures and by food restriction. The combination of our phenotypic and proteomic analysis strongly suggests that NHR-40 provides a link between metabolism and muscle development (en)
|
| Title
| - Proteomic analysis uncovers a metabolic phenotype in C. elegans after
- Proteomická analýza odkryla metabolický fenotyp u C. elegans po snížení funkce nhr-40 (cs)
- Proteomic analysis uncovers a metabolic phenotype in C. elegans after (en)
|
| skos:prefLabel
| - Proteomic analysis uncovers a metabolic phenotype in C. elegans after
- Proteomická analýza odkryla metabolický fenotyp u C. elegans po snížení funkce nhr-40 (cs)
- Proteomic analysis uncovers a metabolic phenotype in C. elegans after (en)
|
| skos:notation
| - RIV/61388971:_____/08:00314175!RIV09-AV0-61388971
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA301/05/0859), P(GA304/07/0529), P(GA304/08/0970), P(LC07017), Z(AV0Z50200510), Z(MSM0021620806)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/08:00314175
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - nuclear hormone receptors; caenorhabditis elegans; nhr-40 (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Biochemical and Biophysical Research Communications
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Novák, Petr
- Šimečková, K.
- Kostrouch, Z.
- Kostrouchová, M.
- Krause, M. W.
- Pohludka, M.
- Vohanka, J.
- Yilma, P.
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)