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| Description
| - Silicosis has progressive, but unpredictable development. There are no markers routinely available to measure the activity and prognosis of silicosis. 8-isoprostane, a marker of oxidative stress and leukotrienes B4, C4, D4, and E4 were measured in exhaled breath condensate in patients with silicosis. Sixty subjects were examined, with mean age 66.7 +/- 2.0 yr and mean exposure to silica 23.6 +/- 2.5 yr. The control group had 25 subjects, with mean age 64.7 +/- 4.8 yr. Exhaled breath was collected using the EcoScreen (Jaeger, Germany); 8-isoprostane and leukotrienes were analyzed by high-performance liquid hromatography/mass spectrometry. Several lung functions parameters were impaired in silicotics in comparisons with the controls; ESR, .alpha.1-antitrypsin and proteinuria were higher in the silicotics. Antineutrophilic cytoplasmic antibodies were more frequent in the silicotics (39%) than in the controls (4%), (p=0.0017).
- Silicosis has progressive, but unpredictable development. There are no markers routinely available to measure the activity and prognosis of silicosis. 8-isoprostane, a marker of oxidative stress and leukotrienes B4, C4, D4, and E4 were measured in exhaled breath condensate in patients with silicosis. Sixty subjects were examined, with mean age 66.7 +/- 2.0 yr and mean exposure to silica 23.6 +/- 2.5 yr. The control group had 25 subjects, with mean age 64.7 +/- 4.8 yr. Exhaled breath was collected using the EcoScreen (Jaeger, Germany); 8-isoprostane and leukotrienes were analyzed by high-performance liquid hromatography/mass spectrometry. Several lung functions parameters were impaired in silicotics in comparisons with the controls; ESR, .alpha.1-antitrypsin and proteinuria were higher in the silicotics. Antineutrophilic cytoplasmic antibodies were more frequent in the silicotics (39%) than in the controls (4%), (p=0.0017). (en)
- Silikóza má progresivní, ale nepředvídatelný vývoj. Neexistují žádné rutinně dostupné markery k měření aktivity a prognózy silikózy. 8-isoprostan, marker oxidativního stresu a leukotrieny B4, C4, D4 a E4 byly měřeny v kondenzátu vydechovaného vzduchu u pacientů se silikózou. Šedesát osob bylo testováno, střední věk 66,7 +/- 2,0 roku a střední expozici křemíku 23,6 +/- 2,5 r. Kontrolní skupina čítala 25 osob, průměrný věk 64,7 +/- 4,8 r. Vydechovaný vzduch byl sbírán pomocí EcoScreen (Jaeger, Germany); 8-isoprostan a leukotrieny byly analyzovány HPLC-MS. Některé parametry plicních funkcí byly zhoršeny proti kontrolní skupině; ESR, .alpha. 1-antitrypsin a proteinurie byly vyšší u silikotiků. Antineutrofilické cytoplazmické protilátky byly častější u silikotiků (39%) než u kontrol (4 %), (p=0.0017). Střední hladina 8-isoprostanu u pacientů se silikózou byla 73,6 +/- 9,9 vs. 43 +/- 10 pg/ml (p=0.0001) u kontrol. (cs)
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| Title
| - 8-Isoprostane and leukotrienes in exhaled breath condensate in czech subjects with silicosis
- 8-Isoprostane and leukotrienes in exhaled breath condensate in czech subjects with silicosis (en)
- 8-izoprostan a leukotrieny v kondenzátu vydechovaného vzduchu u českých osob se silikózou (cs)
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| skos:prefLabel
| - 8-Isoprostane and leukotrienes in exhaled breath condensate in czech subjects with silicosis
- 8-Isoprostane and leukotrienes in exhaled breath condensate in czech subjects with silicosis (en)
- 8-izoprostan a leukotrieny v kondenzátu vydechovaného vzduchu u českých osob se silikózou (cs)
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| skos:notation
| - RIV/61388971:_____/07:00099036!RIV08-AV0-61388971
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR8107), Z(AV0Z40400503), Z(AV0Z50200510)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/07:00099036
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - silica; silicosis; 8-isoprostane; leukotrienes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kačer, P.
- Kuzma, Marek
- Navrátil, Tomáš
- Fenclová, Z.
- Pelclová, D.
- Lebedová, J.
- Klusáčková, P.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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