| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Signální dráha ERK převádí extracelulární signál v rozmanitou škálu specifických intracelulárních buněčných odpovědí jako je buněčné dělení, diferenciace a buněčný pohyb. Specifita buněčné odpovědi do značné míry závisí na tzv. scaffold proteinech které mají schopnost interagovat s jednotlivými komponenty dráhy ERK a určují který signál aktivuje dráhu ERK a také spektrum substrátů proteinkinázy ERK. Protein RACK1 byl identifikován jako scaffold protein, který asociuje s jednotlivými komponenty signální dráhy ERK a je nutný k aktivaci ERK integrinovými receptory. Naše výsledky naznačují, že protein RACK1 umožňuje zacílení proteinkinázy ERK na specifické substráty ve fokálních adhezích. Fosforylace těchto substrátů pak podnítí kontrolované rozložení fokálních adhezí a tím umožní migraci jednotlivých buněk (cs)
- The ERK cascade is activated in response to a broad spectrum of extracellular signals and regulates many cellular responses, including cell growth, cell differentiation and cell motility. The efficiency, specificity, and localization of the ERK signaling pathway could be achieved by scaffold proteins that tether the ERK cascade core kinases and present these enzymes to specific upstream activators and select downstream substrates. We have identified protein RACK1 as a scaffold protein required for integrin dependent activation of the ERK cascade. Our data suggest that RACK1 tethers ERK pathway core kinases, channel signals from upstream activator integrin to downstream targets at focal adhesions, thus promoting focal adhesion turnover and consequently cell motility
- The ERK cascade is activated in response to a broad spectrum of extracellular signals and regulates many cellular responses, including cell growth, cell differentiation and cell motility. The efficiency, specificity, and localization of the ERK signaling pathway could be achieved by scaffold proteins that tether the ERK cascade core kinases and present these enzymes to specific upstream activators and select downstream substrates. We have identified protein RACK1 as a scaffold protein required for integrin dependent activation of the ERK cascade. Our data suggest that RACK1 tethers ERK pathway core kinases, channel signals from upstream activator integrin to downstream targets at focal adhesions, thus promoting focal adhesion turnover and consequently cell motility (en)
|
| Title
| - RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility
- RACK1 spojuje signální dráhu „Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase“ s integriny a tím rozložení fokálních adhezí a následně buněčnou migraci (cs)
- RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility (en)
|
| skos:prefLabel
| - RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility
- RACK1 spojuje signální dráhu „Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase“ s integriny a tím rozložení fokálních adhezí a následně buněčnou migraci (cs)
- RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility (en)
|
| skos:notation
| - RIV/61388971:_____/07:00098523!RIV08-AV0-61388971
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(IAA500200716), Z(AV0Z50200510)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/07:00098523
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - protein kinase; adhesion; cell (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Molecular and Cellular Biology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Vomastek, Tomáš
- Iwanicki, M. P.
- Parsons, J. T.
- Weber, M. J.
- Schaeffer, J.-J.
- Tarcsafalvi, A.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
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