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Description
  • Studovali jsem vliv aminoesterů mastných kyselin, patřících mezi lysosomotropní protihoubové látky (LA), na membránový potenciál a aktivitu MDR pump Pdr5p, Snq2p a Yor1p u S. cerevisiae. V závislosti na chemické struktuře a koncentraci, LA vykazovaly (a) depolarizaci membrány, (b) interakci a MDR pumpami a (c) poškození membrány vedoucí k permeabilizaci buněk. Pouze 3 zkoumané látky interagovaly s MDR pumpami. Relativně malé změny v chemické struktuře způsobily značné rozdíly v typu a velikosti vlivů na buňky (cs)
  • We tested the effects of aminoesters of fatty acids, classed among lysosomotropic antifungals (LA), on membrane potential and the activity of Pdr5p, Snq2p and Yor1p MDR pumps in S. cerevisiae. Depending on their chemical structure and concentration, the LA displayed (a) membrane depolarization, (b) interaction with MDR pumps, and (c) membrane damage leading to cell permeabilization. Only 3 of the tested compounds interacted with the MDR pumps. Relatively small changes in chemical structure led to considerable differences in the mode and magnitude of effects on the cells
  • We tested the effects of aminoesters of fatty acids, classed among lysosomotropic antifungals (LA), on membrane potential and the activity of Pdr5p, Snq2p and Yor1p MDR pumps in S. cerevisiae. Depending on their chemical structure and concentration, the LA displayed (a) membrane depolarization, (b) interaction with MDR pumps, and (c) membrane damage leading to cell permeabilization. Only 3 of the tested compounds interacted with the MDR pumps. Relatively small changes in chemical structure led to considerable differences in the mode and magnitude of effects on the cells (en)
Title
  • Testing the Effect of Lysosomotropic Compounds on Saccharomyces cerevisiae
  • Zkoumání vlivu lysosomotropních látek na Saccharomyces cerevisiae (cs)
  • Testing the Effect of Lysosomotropic Compounds on Saccharomyces cerevisiae (en)
skos:prefLabel
  • Testing the Effect of Lysosomotropic Compounds on Saccharomyces cerevisiae
  • Zkoumání vlivu lysosomotropních látek na Saccharomyces cerevisiae (cs)
  • Testing the Effect of Lysosomotropic Compounds on Saccharomyces cerevisiae (en)
skos:notation
  • RIV/61388971:_____/07:00097503!RIV08-AV0-61388971
http://linked.open.../vavai/riv/strany
  • 82;82
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0570), P(GA301/03/0289), P(GA301/07/0339), Z(AV0Z50200510)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 454840
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/07:00097503
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • aminoesters (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [D9914893E935]
http://linked.open...v/mistoKonaniAkce
  • Smolenice
http://linked.open...i/riv/mistoVydani
  • Bratislava
http://linked.open...i/riv/nazevZdroje
  • Annual Conference on Yeasts /35./. Programme. Abstracts
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Sigler, Karel
  • Kodedová, M.
  • Gášková, D.
  • Hendrych, T.
  • Drietomská, A.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
issn
  • 1336-4839
number of pages
http://purl.org/ne...btex#hasPublisher
  • Slovenská akadémia vied
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