About: A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo

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About: A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Streptococcus pneumoniae má ve svém genomu jediný gen kódujícíc serin-threoninovou proteinkinasu StkP. Biochemické studie provedené s rekombinantní StkP prokázaly, že tento protein je funkční membránovou serin-threoninovou proteinkinasou eukaryotického typu. Prokázali jsme, že delece její extracelulární domény negativně ovlivňuje stabilitu domény kinázové. Naopak, kinázová doména zakotvená v membráně a celá StkP jsou stabilní a schopné autofosforylace. Dále, StkP vytváří dimery skrze transmembránovou a extracelulární domény (cs) Streptococcus pneumoniae carries a single Ser/Thr protein kinase gene stkP in its genome. Biochemical studies performed with recombinant StkP have revealed that this protein is a functional membrane-linked eukaryotic-type Ser/Thr protein kinase. Here, we demonstrate that the deletion of its extracellular domain negatively affects the stability of a core kinase domain. In contrast, the membrane anchored kinase domain and the full-length form of StkP were stable and capable of autophosphorylation. Furthermore, evidence is presented that StkP forms dimers through its transmembrane and extracellular domains Streptococcus pneumoniae carries a single Ser/Thr protein kinase gene stkP in its genome. Biochemical studies performed with recombinant StkP have revealed that this protein is a functional membrane-linked eukaryotic-type Ser/Thr protein kinase. Here, we demonstrate that the deletion of its extracellular domain negatively affects the stability of a core kinase domain. In contrast, the membrane anchored kinase domain and the full-length form of StkP were stable and capable of autophosphorylation. Furthermore, evidence is presented that StkP forms dimers through its transmembrane and extracellular domains (en)
Title	A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo Serin-threoninová proteinkinasa StkP eukaryotického typu Streptococcus pneumoniae působí v podmínkách in vivo jako dimer (cs) A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo (en)
skos:prefLabel	A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo Serin-threoninová proteinkinasa StkP eukaryotického typu Streptococcus pneumoniae působí v podmínkách in vivo jako dimer (cs) A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo (en)
skos:notation	RIV/61388971:_____/07:00085739!RIV08-AV0-61388971
http://linked.open.../vavai/riv/strany	526;530
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/02/1423), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Špidlová, Petra Sasková, Lenka Branny, Pavel Hercík, Kamil Nováková, Linda
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	407882
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/07:00085739
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	autophosphorylation; dimerization; serine/threonine protoein kinase (en)
http://linked.open.../riv/klicoveSlovo	dimerization autophosphorylation serine/threonine protoein kinase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D674BABA706D]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between activity of protein Ser/Thr kinases and inter- and intracellular signalling in differentiating and pathogenical bacterial species
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	355
http://linked.open...iv/tvurceVysledku	Branny, Pavel Hercík, Kamil Nováková, Linda Přenosilová, Lenka Pallová, Petra
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0006-291X
number of pages	5 (xsd:int)

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