About: Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells     Goto   Sponge   NotDistinct   Permalink

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  • K562 is the chronic myelogenous leukemia (CML)-derived cell line that expresses high levels of chimeric oncoprotein Bcr-Abl. The deregulated (permanent) kinase activity of Bcr-Abl leads to continuous proliferation of K562 cells and their resistance to the apoptosis promotion by conventional drugs. The photodynamic treatment (PDT) based on the application of 5-aminolevulinic acid (ALA) and irradiation with blue light (ALA-PDT) resulted in the suppression of K562 cells proliferation. It was followed by a necrosis-like cell death. Further on, we observed several changes in the cytoskeleton organization. In connection with this we uncovered certain cytoskeleton organizing proteins involved in the cell response to the treatment
  • K562 is the chronic myelogenous leukemia (CML)-derived cell line that expresses high levels of chimeric oncoprotein Bcr-Abl. The deregulated (permanent) kinase activity of Bcr-Abl leads to continuous proliferation of K562 cells and their resistance to the apoptosis promotion by conventional drugs. The photodynamic treatment (PDT) based on the application of 5-aminolevulinic acid (ALA) and irradiation with blue light (ALA-PDT) resulted in the suppression of K562 cells proliferation. It was followed by a necrosis-like cell death. Further on, we observed several changes in the cytoskeleton organization. In connection with this we uncovered certain cytoskeleton organizing proteins involved in the cell response to the treatment (en)
  • K562 je buněčná linie odvozená od chronické myeloidní leukémie vykazující vysokou hladinu chimérního onkoproteinu Bcr-Abl. Trvalá kinázová aktivita Bcr-Abl vede k kontinuální proliferaci buněk K562 a jejich resistenci k běžným terepeutikům. Fotodynamická terapie založená na podání 5-aminolevulové kyseliny a následném ozáření modrým světlem vede k potlačení proliferace buněk K562 s následnou buněčnou smrtí. Současně byly pozorovány změny v organizaci cytoskeletonu této buněčné linie (cs)
Title
  • Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells
  • Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells (en)
  • Fotodynamická terapie potlačuje expresi onkogenní kinázi Bcr-Abl a má vliv na cytoskeleton buněk K562 (cs)
skos:prefLabel
  • Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells
  • Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells (en)
  • Fotodynamická terapie potlačuje expresi onkogenní kinázi Bcr-Abl a má vliv na cytoskeleton buněk K562 (cs)
skos:notation
  • RIV/61388971:_____/06:00053411!RIV07-AV0-61388971
http://linked.open.../vavai/riv/strany
  • 205;212
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NL7681), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • -
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 492013
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/06:00053411
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • k562; bcr-abl; photodynamic treatment (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [3F8A8E7A6A61]
http://linked.open...i/riv/nazevZdroje
  • Journal of Photochemistry and Photobiology. B - Biology Section
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 83
http://linked.open...iv/tvurceVysledku
  • Halada, Petr
  • Hrkal, Z.
  • Grebeňová, D.
  • Pluskalová, M.
  • Pešlová, G.
http://linked.open...n/vavai/riv/zamer
issn
  • 1011-1344
number of pages
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