About: The effects of reactive oxygen and nitrogen species during yeast replicative ageing     Goto   Sponge   NotDistinct   Permalink

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Description
  • Volné radikály jsou jednou z nejvýznamnějších příčin stárnutí buněk. Byla sledována tvorba volných radikálů kyslíku a dusíku v divokých a mutatních (Ras aktivace) kmenů kvasinek Saccharomyces cerevisiae, dále hladina lipofuscin pigmentu a alfa tokoferolu (cs)
  • Free radicals are considered the most important cause of cellular ageing. We have compared the wild type strain with the mutant cells with constitutively active Ras oncogen, which generates increased amounts of free radicals. Increased generation of oxygen-derived free radicals resulted in the Ras mutant cells accumulation of lipofuscin-like pigments during ageing. Ageing wild type cells did not accumulate lipofuscin-like pigments. In contrast, the Ras mutant cells contained decreased levels of alpha tocopherol even in the young cells. This observation indicates that the increased free radical generation can overwhelm the endogenous antioxidant system. We have documented the involvement of nitrogen-derived free radicals in the yeast metabolism
  • Free radicals are considered the most important cause of cellular ageing. We have compared the wild type strain with the mutant cells with constitutively active Ras oncogen, which generates increased amounts of free radicals. Increased generation of oxygen-derived free radicals resulted in the Ras mutant cells accumulation of lipofuscin-like pigments during ageing. Ageing wild type cells did not accumulate lipofuscin-like pigments. In contrast, the Ras mutant cells contained decreased levels of alpha tocopherol even in the young cells. This observation indicates that the increased free radical generation can overwhelm the endogenous antioxidant system. We have documented the involvement of nitrogen-derived free radicals in the yeast metabolism (en)
Title
  • The effects of reactive oxygen and nitrogen species during yeast replicative ageing
  • The effects of reactive oxygen and nitrogen species during yeast replicative ageing (en)
  • Úloha kyslíkových a dusíkových radikálů v průběhu replikativního stárnutí (cs)
skos:prefLabel
  • The effects of reactive oxygen and nitrogen species during yeast replicative ageing
  • The effects of reactive oxygen and nitrogen species during yeast replicative ageing (en)
  • Úloha kyslíkových a dusíkových radikálů v průběhu replikativního stárnutí (cs)
skos:notation
  • RIV/61388971:_____/06:00047844!RIV07-GA0-61388971
http://linked.open.../vavai/riv/strany
  • 185;193
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/03/0289), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • 1-4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 473361
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/06:00047844
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • free radicals; lipofuscin-like pigments; nitrotyrosine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [B733F5279360]
http://linked.open...i/riv/nazevZdroje
  • Biofactors
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Pichová, Alena
  • Wilhelm, J.
  • Vytášek, R.
  • Fuksová, H.
  • Schwippelová, Z.
http://linked.open...n/vavai/riv/zamer
issn
  • 0951-6433
number of pages
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