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| rdf:type
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| Description
| - The review %22Bordetella adenylate cyclase toxin: a swift saboteur of host defense%22 summarizes recent findings about structure of adenylate cyclase toxin of Bordetella pertussis and its effects on both immune and respiratory epithelial cells. It has been shown that interaction of adenylate cyclase toxin (CyaA) with epithelial cells aids adhesion of Bordetella to ciliated mucosa and induces production of the pro-inflammatory cytokine interleukin, IL-6. Myeloid phagocytes, attracted to the site of infection are the target of freshly secreted CyaA that binds to CD11b/CD18, penetrates cells and promptly suppresses their bactericidal functions by converting cellular ATP to cAMP. Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen
- The review %22Bordetella adenylate cyclase toxin: a swift saboteur of host defense%22 summarizes recent findings about structure of adenylate cyclase toxin of Bordetella pertussis and its effects on both immune and respiratory epithelial cells. It has been shown that interaction of adenylate cyclase toxin (CyaA) with epithelial cells aids adhesion of Bordetella to ciliated mucosa and induces production of the pro-inflammatory cytokine interleukin, IL-6. Myeloid phagocytes, attracted to the site of infection are the target of freshly secreted CyaA that binds to CD11b/CD18, penetrates cells and promptly suppresses their bactericidal functions by converting cellular ATP to cAMP. Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen (en)
- Publikace %22Bordetella adenylate cyclase toxin: a swift saboteur of host defense%22 je přehledné review, které shrnuje současné znalosti o struktuře adenylátcyklázového toxinu bakterie Bordetella pertussis a jeho účincích na buňky imunitního systému a buňky respiračního epitelu. Ukazuje se, že adenylátcyklázový toxin (CyaA) napomáhá navázání bakterie na řasinkové buňky respiračního epitelu a indukuje sekreci prozánětlivého cytokinu IL-6 z těchto buněk. V případě buněk imunitního systému CyaA po vazbě na receptorovou molekulu CD11b/CD18 proniká do cytozolu, kde katalyzuje neregulovanou přeměnu ATP na cAMP. To vede, kromě inhibice imunitních mechanizmů namířených proti infekci, k částečné maturaci dendritických buněk, a tak pravděpodobně k navození stavu tolerance vůči bakteriím v místě infekce (cs)
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| Title
| - Bordetella adenylate cyclase toxin: a swift saboteur of host defense
- Bordetella adenylate cyclase toxin: a swift saboteur of host defense (en)
- Adenylátcyklázový toxin bakterie Bordetella: pohotový sabotér imunitního systému hostitele (cs)
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| skos:prefLabel
| - Bordetella adenylate cyclase toxin: a swift saboteur of host defense
- Bordetella adenylate cyclase toxin: a swift saboteur of host defense (en)
- Adenylátcyklázový toxin bakterie Bordetella: pohotový sabotér imunitního systému hostitele (cs)
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| skos:notation
| - RIV/61388971:_____/06:00040412!RIV07-MSM-61388971
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0506), P(IAA5020406), Z(AV0Z50200510)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/06:00040412
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - cyaa; scanning electron microscopy; cyclase toxin (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Current Opinion in Microbiology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kamanová, Jana
- Šebo, Peter
- Vojtová, Jana
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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